Cytokine signal regulation and autoimmune disorders
Cytokine signal regulation and autoimmune disorders
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DOI：
10.1080/08916930500124106
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发表时间：
2005-08-01
期刊：
影响因子：
3.5
通讯作者：
Nishimoto, N
中科院分区：
文献类型：
--
作者：
Nishimoto, N
随着对细胞因子生物学活性及其调控机制的深入了解，在类风湿性关节炎（RA）和克罗恩病（Crohn's disease）等自身免疫性炎症性疾病中，通过应用促炎性细胞因子和抗炎性细胞因子或细胞因子抑制剂来恢复两者之间的失衡，从而促进了治疗的理念。应用分子生物学技术设计单克隆抗体、可溶性受体或受体拮抗剂作为治疗生物制剂，使调节细胞因子信号治疗传统疗法难以治疗的疾病成为可能。日本研究人员在自身免疫性疾病细胞因子信号调节的研究方面做出了巨大贡献。本文综述了日本在自身免疫性疾病中细胞因子信号调节，特别是白细胞介素-6（IL-6）的研究。
Understanding of biological activities of cytokines and exquisite mechanism to regulate their functions has facilitated the therapeutic concept to restore the disequilibrium between pro-inflammatory cytokines and anti-inflammatory cytokines or cytokine inhibitors in some autoimmune inflammatory diseases such as rheumatoid arthritis (RA) and Crohn's disease. The application of molecular biology techniques to design monoclonal antibodies, soluble receptors, or receptor antagonists as therapeutic biologic agents made it possible to regulate the cytokine signals for the treatment of the diseases refractory to conventional therapies.Japanese researchers have contributed considerably to the establishment of cytokine signal regulation in autoimmune diseases. In this article, Japanese studies of cytokine signal regulation, particularly for Interleukin-6 (IL-6) in autoimmune diseases are reviewed.