Effects of polybrominated biphenyls (PBB) on immune response in rodents.
Effects of polybrominated biphenyls (PBB) on immune response in rodents.
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多溴联苯 (PBB) 对啮齿动物免疫反应的影响。
DOI：
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发表时间：
1978
影响因子：
10.4
通讯作者：
J. Moore
中科院分区：
文献类型：
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作者：
M. Luster;R. Faith;J. Moore
研究了由多溴联苯（PBB）混合物组成的化学阻燃剂FireMaster FF-1对小鼠和大鼠免疫功能的影响。在为期30天的时间内，动物每天接受22次0.03、0.3、3.0或30毫克多溴联苯/公斤体重的治疗。多溴联苯暴露在较高剂量水平下严重抑制了小鼠和大鼠的细胞介导的免疫力，如脾淋巴细胞对多克隆T细胞激活剂促有丝分裂刺激的反应性降低所示。此外，在30.0 ppm剂量水平下，小鼠的体液免疫力受到抑制。体液免疫功能测定包括抗体产生、血清免疫球蛋白水平和脾淋巴细胞对多克隆B细胞激活剂的促有丝分裂刺激。这些研究表明，接触多溴联苯可导致抑制体液免疫反应，特别是细胞介导的免疫反应。
Studies were performed to investigate the effects of FireMaster FF-1, a chemical fire retardant consisting of a mixture of polybrominated biphenyls (PBB), on immune functions in mice and rats. Animals received 22 daily treatments of 0.03, 0.3, 3.0, or 30 mg PBB/kg body weight in a period covering 30 days. PBB exposure severely depressed cell mediated immunity in both mice and rats at the higher dosage levels as indicated by depressed responsiveness of splenic lymphocytes to mitogenic stimulation by polyclonal T-cell activators. Additionally, humoral immunity was depressed in mice at the 30.0 ppm dosage level. Assays for humoral immune functions included antibody production, serum immunoglobulin levels, and mitogenic stimulation of splenic lymphocytes to a polyclonal B-cell activator. These studies indicate that PBB exposure can lead to suppression of both humoral and particularly cell-mediated immune responses.