Organization of ventral tegmental area projections to the ventral tegmental area-nigral complex in the rat
Organization of ventral tegmental area projections to the ventral tegmental area-nigral complex in the rat
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DOI：
10.1016/j.neuroscience.2008.02.003
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发表时间：
2008-04-22
期刊：
影响因子：
3.3
通讯作者：
Shammah-Lagnado, S. J.
中科院分区：
文献类型：
--
作者：
Ferreira, J. G. P.;Del-Fava, F.;Shammah-Lagnado, S. J.
腹侧被盖区（VTA）是奖赏回路中的一个节点。基于其纹状体输出，其已被细分为靶向腹内侧纹状体的尾内侧部分和靶向腹外侧纹状体的外侧部分[Ikemoto S（2007）Dopamine reward circuitry：two projection systems from the ventral midbrain to the nucleus-olfactory tubercle complex. Brain Res Rev 56：27-78]。这两个VTA部分是否相互联系，以及VTA在多大程度上支配黑质和红核后核是理解基底神经节信息处理的关键问题。在这里，腹侧被盖投射到腹侧被盖-黑质复合体进行了检查，使用菜豆白细胞凝集素（PHA-L）作为顺行示踪剂。结果表明，背外侧VTA的项目本身，以及到SNc和RR的背侧层，在很大程度上避免尾内侧VTA。腹外侧腹侧被盖区主要支配束间核。腹侧被盖区尾内侧核的组成部分（束间核、黑质旁核和尾侧线性核）相互连接。此外，尾内侧腹侧被盖区（尤其是黑质旁核和尾侧线性核）支配腹侧被盖区外侧，并在较小程度上支配SNc和RR。腹侧被盖区的尾极向几乎所有的腹侧被盖区-黑质复合体发出强有力的双侧投射，该复合体终止于背侧和腹侧层。适度的输入从内侧乳头体上核腹内侧部分的腹侧被盖-黑质复合体也被确定。在双重免疫染色切片中，PHA-L标记的静脉曲张有时被发现与中脑腹侧酪氨酸羟化酶阳性神经元并列。总体而言，结果强调，VTA预测的VTA黑质复合体是实质性的，局部组织。一般来说，这些投射，像螺旋状的纹状体-黑质-纹状体环，显示出内侧到外侧的组织结构。这种解剖学上的排列方式可以使腹内侧纹状体影响外侧纹状体的活动。尾极的腹侧被盖区似乎是一个关键网站的全球招聘的mesotelencephalic系统。(C)2008年IBRO。由爱思唯尔有限公司出版。保留所有权利。
The ventral tegmental area (VTA) is a nodal link in reward circuitry. Based on its striatal output, it has been subdivided in a caudomedial part which targets the ventromedial striatum, and a lateral part which targets the ventrolateral striatum [Ikemoto S (2007) Dopamine reward circuitry: two projection systems from the ventral midbrain to the nucleus accumbens-olfactory tubercle complex. Brain Res Rev 56:27-78]. Whether these two VTA parts are interconnected and to what extent the VTA innervates the substantia nigra compacta (SNc) and retrorubral nucleus (RR) are critical issues for understanding information processing in the basal ganglia. Here, VTA projections to the VTA-nigral complex were examined in rats, using Phaseolus vulgaris leucoagglutinin (PHA-L) as anterograde tracer. The results show that the dorsolateral VTA projects to itself, as well as to the dorsal tier of the SNc and RR, largely avoiding the caudomedial VTA. The ventrolateral VTA innervates mainly the interfascicular nucleus. The components of the caudomedial VTA (the interfascicular, paranigral and caudal linear nuclei) are connected with each other. In addition, the caudomedial VTA (especially the paranigral and caudal linear nuclei) innervates the lateral VTA, and, to a lesser degree, the SNc and RR. The caudal pole of the VTA sends robust, bilateral projections to virtually all the VTA-nigral complex, which terminate in the dorsal and ventral tiers. Modest inputs from the medial supramammillary nucleus to ventromedial parts of the VTA-nigral complex were also identified. In double-immunostained sections, PHA-L-labeled varicosities were sometimes found apposed to tyrosine hydroxylase-positive neurons in the ventral mesencephalon. Overall, the results underscore that VTA projections to the VTA-nigral complex are substantial and topically organized. In general, these projections, like the spiralated striato-nigro-striatal loops, display a medial-to-lateral organization. This anatomical arrangement conceivably permits the ventromedial striatum to influence the activity of the lateral striatum. The caudal pole of the VTA appears to be a critical site for a global recruitment of the mesotelencephalic system. (C) 2008 IBRO. Published by Elsevier Ltd. All rights reserved.