The change of the quantitative HBsAg level during the natural course of chronic hepatitis B
The change of the quantitative HBsAg level during the natural course of chronic hepatitis B
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DOI：
10.1111/j.1478-3231.2011.02516.x
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发表时间：
2011-07-01
影响因子：
6.7
通讯作者：
Paik, Seung W.
中科院分区：
文献类型：
--
作者：
Kim, Yu J.;Cho, Hyun C.;Paik, Seung W.
目的了解慢性乙型病毒性肝炎(CHB)不同阶段的HBs Ag水平及其与血清HBVDNA的关系，探讨其与HBVDNA水平的相关性。其中免疫耐受(IT)56例，HBeAg阳性肝炎(EPH)150例，非活动性携带者(IC)274例，HBeAg阴性肝炎(ENH)165例。结果乙肝表面抗原平均滴度(logIU/ml)分别为IT4.29、EPH3.64、IC2.05和ENH3.23(P<；0.001)。与HBVdna呈显著正相关(r=0.693，P=0.001)，IT组、EPH组、IC组也有显著相关性(r=0.664，r=0.541，r=0.505，P均<0.001)，而ENH组无相关性(r=0.093，P=0.321)。年龄与乙肝表面抗原呈负相关(r=-0.451，P<0.001)。肝硬化组明显低于非肝硬化组(2.41+/-1.36vs.3.02+/-1.21logIU/ml，P<；0.001)。结论慢性乙型病毒性肝炎不同阶段的HBs Ag水平有显著差异，且与HBVDNA呈正相关。这些发现可以为了解慢性乙型肝炎的自然病程和发病机制提供更多的信息。
BackgroundThere is insufficient information about HBsAg levels and their correlation with serum hepatitis B virus (HBV) DNA in chronic hepatitis B (CHB).AimsWe aimed to describe HBsAg levels during various phases of CHB and to investigate the correlation with serum HBV DNA levels.MethodsA total of 645 treatment-naive Korean CHB patients were included in this retrospective cross-sectional study. They were categorized into immune tolerance (IT, n=56), HBeAg-positive hepatitis (EPH, n=150), inactive carrier (IC, n=274) and HBeAg-negative hepatitis (ENH, n=165). The baseline HBsAg and HBV DNA levels were measured.ResultsThe mean HBsAg titres (log IU/ml) differed (P < 0.001): IT 4.29, EPH 3.64, IC 2.05 and ENH 3.23. In 645 patients, HBsAg and HBV DNA showed a significant correlation (r=0.693, P < 0.001), and this was also observed in the IT, EPH and IC groups (r=0.664, r=0.541, r=0.505, respectively, all P < 0.001), but not in the ENH group (r=0.093, P=0.321). Age had a negative correlation with HBsAg (r=-0.451, P < 0.001). The cirrhotic patients had a significantly lower HBsAg level than the non-cirrhotic patients (2.41 +/- 1.36 vs. 3.02 +/- 1.21 log IU/ml, P < 0.001).ConclusionsThe HBsAg level varied significantly in different phases of CHB and was correlated with HBV DNA during the IT, EPH and IC phases. These findings can provide additional information to understand the natural course and pathogenesis of CHB.