Coronary heart disease and its risk factors in first-generation immigrant Asian Indians to the United States of America.
Coronary heart disease and its risk factors in first-generation immigrant Asian Indians to the United States of America.
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发表时间：
1996-07
影响因子：
1.5
通讯作者：
E. Enas;A. Garg;Michael A. Davidson;V. Nair;B. Huet;S. Yusuf
中科院分区：
文献类型：
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作者：
E. Enas;A. Garg;Michael A. Davidson;V. Nair;B. Huet;S. Yusuf
比较了第一代移居美国的亚裔印度人与当地高加索人的冠心病(CHD)患病率及其危险因素。共有1688名亚裔印度医生及其家庭成员(1131名男性和557名女性，年龄和年龄=20岁)完成了一份问卷调查，并在580名受试者中测定了血清脂蛋白。与弗雷明翰后代研究(7.2%比2.5%；P<；0.0001)相比，亚裔印度男性的年龄调整后心肌梗死和/或心绞痛的患病率大约高出三倍，但在女性中相似(0.3%比1%；P=0.64)。亚裔印度人的非胰岛素依赖型糖尿病患病率较高(7.6%比1%；p<；0.0001)，但吸烟(1.3%比27%；p<；0.0001)和肥胖(4.2%比22%；p<；0.0001)的患病率明显较低。高血压在亚裔印度男性中的患病率较低(14.2%比19.1%，p<；0.008)，但在女性中相似(11.3%比11.4%)。男性低密度脂蛋白胆固醇水平升高的发生率与男性相似[分别为17%对23.4%(p=0.24)和13.7%对22.3%(p=0.22)]，但女性较低[分别为15%对26.1%(p=0.018)和14.3%对19.6%(p=0.047)]。年轻(30-39岁)亚裔印度男性(平均值：0.98vs1.18mmos/L；p<；0.001)和中年(30-59岁)女性(平均值：1.24vs1.45mmol/L；p<；0.001)的高密度脂蛋白胆固醇平均水平较低。高甘油三酯血症的患病率在男性中相似(18.5%比11.3%)，但在亚裔印度女性中更高(8.3%比4.1%，p=0.02)。总而言之，移民到美国的亚裔印度男性有很高的冠心病、NIDDM、低高密度脂蛋白水平和高甘油三酯血症的患病率。所有这些都将胰岛素抵抗作为一种常见的发病机制，似乎是最重要的危险因素。
The prevalence of coronary heart disease (CHD) and its risk factors in first-generation Asian Indian immigrants to the United States of America (US) were compared with those of the native Caucasian population. A total of 1688 Asian Indian physicians and their family members (1131 men and 557 women, age > or = 20 years) completed a questionnaire and in 580 subjects serum lipoproteins were determined. The age-adjusted prevalence of myocardial infarction and/or angina was approximately three times more in Asian Indian men compared to the Framingham Offspring Study (7.2% versus 2.5%; P < 0.0001) but was similar in women (0.3% versus 1%; p = 0.64). Asian Indians had higher prevalence of noninsulin-dependent diabetes mellitus (NIDDM; 7.6% versus 1%; p < 0.0001) but markedly lower prevalence of cigarette smoking (1.3% versus 27%; p < 0.0001) and obesity (4.2% versus 22%; p < 0.0001). Hypertension was less prevalent in Asian Indian men 14.2% versus 19.1%, p < 0.008) but similar in women (11.3% versus 11.4%). The prevalence of elevated total a low-density lipoprotein (LDL) cholesterol levels was similar in men [17% versus 23.4% (p = 0.24) and 13.7% versus 22.3% (p = 0.22), respectively] but lower in women [15% versus 26.1% (p = 0.018) and 14.3% versus 19.6% (p = 0.047) respectively]. The mean levels of high-density lipoprotein (HDL) cholesterol were less in younger (30-39 years) Asian Indian men (mean: 0.98 versus 1.18 mmol/l; p < 0.001) and middle-aged (30-59 years) women (mean: 1.24 versus 1.45 mmol/l; p < 0.001). The prevalence of hypertriglyceridaemia was similar in men (18.5% versus 11.3%), but higher in Asian Indian women (8.3% versus 4.1%, p = 0.02). To conclude, immigrant Asian Indian men to the US have high prevalence of CHD, NIDDM, low HDL cholesterol levels and hypertriglyceridaemia. All these have "insulin resistance" as a common pathogenetic mechanism and seem to be the most important risk factors.