Accelerator or Brake: Immune Regulators in Malaria.

Accelerator or Brake: Immune Regulators in Malaria.
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加速器还是刹车:疟疾中的免疫调节器

DOI:
10.3389/fcimb.2020.610121
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发表时间:
2020
影响因子:
5.7
通讯作者:
Yu X
Yu X
中科院分区:
医学2区
文献类型:
--
作者:
Cai C;Hu Z;Yu X

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疟疾是一种威胁生命的传染病,全世界每年有超过2.5亿人受到影响,根除疟疾是世纪来公共卫生面临的最大挑战之一。对抗寄生虫疗法的耐药性日益增强和缺乏有效疫苗是控制这一疾病的主要因素。然而,对寄生虫与宿主抗疟疾免疫力相互作用的不完全理解阻碍了迄今为止的疫苗开发工作。最近的研究已经揭示了针对疟原虫感染的免疫应答和调节剂的复杂性。在这里,我们总结了我们目前对疟原虫衍生成分感染的宿主免疫反应的理解,主要集中在最近确定的免疫调节剂协调抗疟疾免疫介导的各种调节机制。
Malaria is a life-threatening infectious disease, affecting over 250 million individuals worldwide each year, eradicating malaria has been one of the greatest challenges to public health for a century. Growing resistance to anti-parasitic therapies and lack of effective vaccines are major contributing factors in controlling this disease. However, the incomplete understanding of parasite interactions with host anti-malaria immunity hinders vaccine development efforts to date. Recent studies have been unveiling the complexity of immune responses and regulators against Plasmodium infection. Here, we summarize our current understanding of host immune responses against Plasmodium-derived components infection and mainly focus on the various regulatory mechanisms mediated by recent identified immune regulators orchestrating anti-malaria immunity.
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