The diversity of experimental organisms in biomedical research may be influenced by biomedical funding
The diversity of experimental organisms in biomedical research may be influenced by biomedical funding
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DOI：
10.1002/bies.201600258
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发表时间：
2017-05-01
期刊：
影响因子：
4
通讯作者：
Laubichler, Manfred D.
中科院分区：
文献类型：
--
作者：
Peirson, B. R. Erick;Kropp, Heather;Laubichler, Manfred D.
与一些批评家的担忧相反，我们提出的证据表明，生物医学研究并不是由一小撮模型生物主导的。对研究文献的详尽分析表明，自1975年以来，生物医学研究中实验生物体的多样性已大幅增加。长期以来，人们一直担心，以生物体为中心的资金政策可能会导致实验生物体选择上的偏见，从而对研究方向和结果的解释产生负面影响。批评人士认为，对模式生物的关注不适当地限制了实验生物的多样性。科学文献的大型电子数据库的可获得性，再加上科学哲学家对定量方法的兴趣，为生物医学研究中的有机体选择的数据驱动调查提供了新的机会。美国国立卫生研究院资助的研究中使用的生物多样性可能比更广泛的生物医学科学中使用的生物多样性低得多，并且可能在生物选择方面受到更大的限制。
Contrary to concerns of some critics, we present evidence that biomedical research is not dominated by a small handful of model organisms. An exhaustive analysis of research literature suggests that the diversity of experimental organisms in biomedical research has increased substantially since 1975. There has been a longstanding worry that organism-centric funding policies can lead to biases in experimental organism choice, and thus negatively impact the direction of research and the interpretation of results. Critics have argued that a focus on model organisms has unduly constrained the diversity of experimental organisms. The availability of large electronic databases of scientific literature, combined with interest in quantitative methods among philosophers of science, presents new opportunities for data-driven investigations into organism choice in biomedical research. The diversity of organisms used in NIH-funded research may be considerably lower than in the broader biomedical sciences, and may be subject to greater constraints on organism choice.