Alterations in expression of measles virus polypeptides by antibody: molecular events in antibody-induced antigenic modulation.
Alterations in expression of measles virus polypeptides by antibody: molecular events in antibody-induced antigenic modulation.
复制标题
抗体对麻疹病毒多肽表达的改变：抗体诱导的抗原调节中的分子事件。
DOI：
10.4049/jimmunol.125.1.78
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发表时间：
1980
影响因子：
4.4
通讯作者：
M. Oldstone
中科院分区：
文献类型：
--
作者：
R. Fujinami;M. Oldstone
在麻疹病毒抗体与急性感染麻疹病毒的HeLa细胞表面结合6小时后，外源多肽F1以及内源多肽P和M的表达发生改变。抗体诱导的抗原调节过程中F1分子的丢失解释了在抗体存在下培养的感染细胞缺乏细胞-细胞融合和巨细胞形成的原因。F1、P和M病毒多肽的减少是特定的，因为这种作用只对针对细胞表面表达的麻疹病毒抗原的抗体起作用，而对针对病毒感染细胞表面表达的非病毒抗原的抗体没有影响。由于P蛋白或其类似物在其他病毒系统中似乎与转录复合体有关，而M蛋白与核衣壳在质膜上的识别和排列有关，这些多肽的变化可能导致麻疹病毒合成和成熟的异常，这是麻疹病毒持续感染的特征。
Six hours after measles virus antibodies bind to the surface of HeLa cells acutely infected with measles virus, the expression of an external polypeptide F1, as well as internal polypeptides P and M are altered. The loss of F1 molecules during antibody-induced antigenic modulation explains the lack of cell-cell fusion and giant cell formation of infected cells cultured in the presence of antibody. The decrease in F1, P, and M viral polypeptides is specific, since the effect is only seen with antibodies directed against measles virus antigens expressed on the cell's surface and not with antibodies directed against nonviral antigens expressed on the surfaces of virus-infected cells. Since the P protein or its analog in other viral systems appears to be associated with transcriptive complex whereas the M protein is associated with nucleocapsid recognition and alignment at the plasma membrane, the alterations in these polypeptides might lead to aberrations in measles virus synthesis and maturation that are hallmarks of persistent measles virus infection.