Changes in body fat and weight after a breast cancer diagnosis: Influence of demographic, prognostic, and lifestyle factors
Changes in body fat and weight after a breast cancer diagnosis: Influence of demographic, prognostic, and lifestyle factors
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DOI：
10.1200/jco.2005.04.036
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发表时间：
2005-02-01
影响因子：
45.3
通讯作者：
Ballard-Barbash, R
中科院分区：
文献类型：
--
作者：
Irwin, ML;McTiernan, A;Ballard-Barbash, R
目的 与瘦女性和诊断后体重不增加的女性相比，肥胖女性和乳腺癌诊断后体重增加的女性乳腺癌复发和死亡的风险更大。在这项基于人群的研究中，我们评估了 514 名患有 0-IIIA 期乳腺癌的女性从诊断第一年到诊断后第三年的体重和体脂变化，以及体重和体脂的变化是否因人口统计学、预后和生活方式因素而变化。 方法 患者是健康、饮食、活动和生活方式 (HEAL) 研究的参与者。在基线访视期间和 2 年后的随访访视期间测量体重和体脂（通过双能 X 射线吸收测定法扫描）。使用协方差分析方法来获得针对潜在共同创始人进行调整的平均体重和体脂变化。结果从诊断第一年到诊断第三年，女性的体重和体脂百分比分别增加了 1.7 +/- 4.7 kg 和 2.1% +/- 3.9%。共有 68% 和 74% 的患者体重和体脂分别增加。在诊断为疾病分期较高、年龄较小、绝经后的女性以及从诊断到诊断后 3 年内体力活动减少的女性中，体重增加幅度更大（趋势 P < .05）。 结论 诊断后期间体重和体脂增加。未来的研究应重点关注体力活动对体重和脂肪减少以及乳腺癌预后的影响。
Purpose Obese women and women who gain weight after a breast cancer diagnosis are at a greater risk for breast cancer recurrence and death compared with lean women and women who do not gain weight after diagnosis. In this population-based study, we assessed weight and body fat changes from during the first year of diagnosis to during the third year after diagnosis, and whether any changes in weight and body fat varied by demographic, prognostic, and lifestyle factors in 514 women with incident Stage 0-IIIA breast cancer.Methods Patients were participants in the Health, Eating, Activity, and Lifestyle (HEAL) study. Weight and body fat (via dual-energy x-ray absorptiometry scans) were measured during the baseline visit and 2 years later at a follow-up visit. Analysis of covariance methods were used to obtain mean weight and body fat changes adjusted for potential cofounders.Results Women increased their weight and percent body fat by 1.7 +/- 4.7 kg and 2.1% +/- 3.9%, respectively, from during their first year of diagnosis to during their third year of diagnosis. A total of 68% and 74% of patients gained weight and body fat, respectively. Greater increases in weight were observed among women diagnosed with a higher disease stage, younger age, being postmenopausal, and women who decreased their physical activity from diagnosis to up to 3 years after diagnosis (P for trend < .05).Conclusion Weight and body fat increased in the postdiagnosis period. Future research should focus on the effect of physical activity on weight and fat loss and breast cancer prognosis.