Implementing Nonlinear Feedback Controllers Using DNA Strand Displacement Reactions
Implementing Nonlinear Feedback Controllers Using DNA Strand Displacement Reactions
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DOI：
10.1109/tnb.2016.2560764
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发表时间：
2016-07-01
影响因子：
3.9
通讯作者：
Bates, Declan G.
中科院分区：
文献类型：
--
作者：
Sawlekar, Rucha;Montefusco, Francesco;Bates, Declan G.
我们展示了一类重要的非线性反馈控制器如何使用理想化的抽象化学反应来设计，并通过DNA链位移（DSD）反应来实现。利用化学反应网络（crn）作为设计复杂电路和网络的编程语言，我们展示了如何使用一组单分子和双分子反应来实现输入输出动力学，从而产生非线性准滑模（QSM）反馈控制器。所需化学反应的动力学可以实现为无酶，焓/熵驱动的DNA反应，通过沃森-克里克碱基配对和分支迁移，使用支点介导的链位移机制。我们证明了非线性QSM控制器的闭环响应优于传统的线性控制器，因为它促进了更快的跟踪响应动力学，而不会在瞬态响应中引入超调。所得到的控制器是高度模块化的，与标准线性设计相比，受追溯效应的影响较小。
We show how an important class of nonlinear feedback controllers can be designed using idealized abstract chemical reactions and implemented via DNA strand displacement (DSD) reactions. Exploiting chemical reaction networks (CRNs) as a programming language for the design of complex circuits and networks, we show how a set of unimolecular and bimolecular reactions can be used to realize input-output dynamics that produce a nonlinear quasi sliding mode (QSM) feedback controller. The kinetics of the required chemical reactions can then be implemented as enzyme-free, enthalpy/entropy driven DNA reactions using a toehold mediated strand displacement mechanism via Watson-Crick base pairing and branch migration. We demonstrate that the closed loop response of the nonlinear QSM controller outperforms a traditional linear controller by facilitating much faster tracking response dynamics without introducing overshoots in the transient response. The resulting controller is highly modular and is less affected by retroactivity effects than standard linear designs.