ENDOTOXIN REMOVAL BY CHARGE-MODIFIED FILTERS
ENDOTOXIN REMOVAL BY CHARGE-MODIFIED FILTERS
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DOI：
10.1128/aem.50.6.1375-1377.1985
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发表时间：
1985-01-01
影响因子：
4.4
通讯作者：
HOU, K
中科院分区：
文献类型：
--
作者：
GERBA, CP;HOU, K
评价了带正电的尼龙过滤器和深度过滤器(纤维素-硅藻土)对不同溶液中内毒素的去除效果。带电的过滤介质去除了自来水、水、蒸馏水、糖和氯化钠溶液中大量的大肠杆菌和天然内毒素；带负电的过滤介质没有观察到显著的内毒素去除。去除程度受pH、盐的存在和有机物的影响。这种介质可用于控制原料水或用于制备非肠外药物产品的溶液中的内毒素，或需要内毒素控制的其他液体中的内毒素。
The effects of positively charged nylon and depth (cellulose-diatomaceous earth)filters on endotoxin removal from various solutions were evaluated. The charged filter media removed significant amounts of Escherichia coli and natural endotoxin from tap, water, distilled water, sugars, and NaCl solutions; no significant removal of endotoxin was observed with negatively charged filter media. The extent of removal was influenced by pH, the presence of salts, and organic matter. Such media may be useful for the control of endotoxins in raw-product water or solutions used to prepare parenteral drug products or in other fluids where endotoxin control is desired.