Running wheel exercises accelerate neuronal turnover in mouse dentate gyrus
Running wheel exercises accelerate neuronal turnover in mouse dentate gyrus
复制标题
DOI：
10.1016/j.neures.2006.05.006
复制
发表时间：
2006-09-01
影响因子：
2.9
通讯作者：
Sugiyama, Hiroyuki
中科院分区：
文献类型：
--
作者：
Kitamura, Takashi;Sugiyama, Hiroyuki
小鼠齿状回的神经发生在整个成年期持续，并受到环境、内分泌和药理学条件的影响。虽然有报道说跑轮运动可以增强神经发生，但是对齿状回神经元死亡的影响还不清楚。神经元的产生和消除的精确控制被认为对于维持成人神经系统中相对恒定数量的神经元和调节成人脑功能是重要的。我们在这里报告说，跑轮运动增强了死亡的预先存在的神经元，以及在齿状回的神经发生。此外，我们分析了缺乏NMDA受体F1亚基的小鼠，发现在F1亚基敲除小鼠中，运动对神经元死亡的增强作用受到抑制。这些结果表明，跑轮运动通过激活NMDA受体加速小鼠齿状回神经元的周转。(c)2006年Elsevier爱尔兰有限公司和日本神经科学学会。All rights reserved.
Neurogenesis continues throughout adulthood in mouse dentate gyrus, and is influenced by environmental, endocrine, and pharmacological conditions. Although running wheel exercises have been reported to enhance neurogenesis, the effects on neuronal death in dentate gyrus are not well understood. The precise control of the production and elimination of neurons is thought to be important for the maintenance of a relatively constant number of neurons in the adult nervous system and for the regulation of adult brain function. We report here that running wheel exercises enhance the death of pre-existing neurons as well as neurogenesis in dentate gyrus. In addition, we analyzed mice lacking an NMDA receptor F I subunit, and found that the enhancement of the neuronal death by the exercises is suppressed in the epsilon 1 subunit knockout mice. These results suggest that running wheel exercises accelerate neuronal turnover in mouse dentate gyrus, through the activation of NMDA receptors. (c) 2006 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.