SIGNAL INTEGRATION AT THE LEVEL OF PROTEIN-KINASES, PROTEIN PHOSPHATASES AND THEIR SUBSTRATES
SIGNAL INTEGRATION AT THE LEVEL OF PROTEIN-KINASES, PROTEIN PHOSPHATASES AND THEIR SUBSTRATES
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DOI：
10.1016/0968-0004(92)90010-7
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发表时间：
1992-10-01
影响因子：
13.8
通讯作者：
COHEN, P
中科院分区：
文献类型：
--
作者：
COHEN, P
蛋白质磷酸化和去磷酸化是真核细胞信号整合的主要机制之一。它可以通过控制第二信使水平的蛋白质的磷酸化，通过蛋白激酶和磷酸酶本身的磷酸化，或通过其底物的可逆磷酸化来实现。本文还强调了“多位点磷酸化”在信号整合中的重要作用，其中不同的蛋白激酶通过磷酸化单个蛋白质中的不同Ser或Thr残基而对活性产生相加、协同和拮抗作用。
Protein phosphorylation and dephosphorylation is one of the major mechanisms of signal integration in eukaryotic cells. It can be achieved through the phosphorylation of proteins that control the levels of second messengers, through the phosphorylation of protein kinases and phosphatases themselves, or through the reversible phosphorylation of their substrates. This article also highlights the important role of 'multi-site phosphorylation' in signal integration, in which different protein kinases produce additive, synergistic and antagonistic effects on activity by phosphorylating distinct Ser or Thr residues in a single protein.