Functional imaging of neural responses to expectancy and experience of monetary gains and losses
Functional imaging of neural responses to expectancy and experience of monetary gains and losses
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DOI：
10.1016/s0896-6273(01)00303-8
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发表时间：
2001-05-01
期刊：
影响因子：
16.2
通讯作者：
Shizgal, P
中科院分区：
文献类型：
--
作者：
Breiter, HC;Aharon, I;Shizgal, P
通过功能性磁共振成像监测伴随对金钱收益和损失的预期及体验的神经反应。试验包括一个初始的“预期”阶段，此时显示一组三个金额，以及随后的“结果”阶段，此时其中一个金额被给予。豆状核下延伸的杏仁核（SLEA）和眶回的血流动力学反应追踪预期的预期值，并且对最高价值结果组的反应在伏隔核、SLEA和下丘脑中随金钱价值单调增加。对预期和结果的反应通常，但不总是，在相同区域被观察到。观察到的激活与先前在对触觉刺激、味觉刺激和致欣快药物的反应中看到的激活的重叠，与共同回路对不同奖励的处理的作用是一致的。
Neural responses accompanying anticipation and experience of monetary gains and losses were monitored by functional magnetic resonance imaging. Trials comprised an initial "prospect" (expectancy) phase, when a set of three monetary amounts was displayed, and a subsequent "outcome" phase, when one of these amounts was awarded. Hemodynamic responses in the sublenticular extended amygdala (SLEA) and orbital gyrus tracked the expected values of the prospects, and responses to the highest value set of outcomes increased monotonically with monetary value in the nucleus accumbens, SLEA, and hypothalamus. Responses to prospects and outcomes were generally, but not always, seen in the same regions. The overlap of the observed activations with those seen previously in response to tactile stimuli, gustatory stimuli, and euphoria-inducing drugs is consistent with a contribution of common circuitry to the processing of diverse rewards.