Dysconnectivity in Schizophrenia Revisited: Abnormal Temporal Organization of Dynamic Functional Connectivity in Patients With a First Episode of Psychosis.
Dysconnectivity in Schizophrenia Revisited: Abnormal Temporal Organization of Dynamic Functional Connectivity in Patients With a First Episode of Psychosis.
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DOI：
10.1093/schbul/sbac187
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发表时间：
2022-12
影响因子：
6.6
通讯作者：
Juan P. Ramirez-Mahaluf;Ángeles Tepper;L. M. Alliende;Carlos Mena;C. Castañeda;Barbara Iruretagoyena;Rubén Nachar;Francisco Reyes-Madrigal;P. León-Ortíz;Ricardo Mora-Durán;T. Ossandón;Alfonso González-Valderrama;J. Undurraga;C. de la Fuente-Sandoval;N. Crossley
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文献类型：
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作者：
Juan P. Ramirez-Mahaluf;Ángeles Tepper;L. M. Alliende;Carlos Mena;C. Castañeda;Barbara Iruretagoyena;Rubén Nachar;Francisco Reyes-Madrigal;P. León-Ortíz;Ricardo Mora-Durán;T. Ossandón;Alfonso González-Valderrama;J. Undurraga;C. de la Fuente-Sandoval;N. Crossley
背景与假设精神分裂症患者脑区之间的异常功能连接是一个一致的发现，包括功能性磁共振成像（fMRI）研究。最近的研究强调了健康受试者的连接性随时间变化。我们在这里研究了首次发作精神病（FEP）患者的功能连接的时间变化。具体来说，我们分析了访问全脑组织状态的时间顺序。研究设计两个病例对照研究，包括在每个样本的亚组扫描治疗后的第二次。智利样本包括79名FEP患者和83名健康对照。墨西哥样本包括21名抗精神病药物初治的FEP患者和15名健康对照。全脑功能连接元状态之间的时间轨迹的特点进行了检查，通过静息态功能磁共振成像使用网络科学的元素。我们比较了病例组和对照组，并探讨了他们的差异以及与症状，认知和抗精神病药物剂量的潜在关联。研究结果我们发现病人的脑动力学访问不同状态的时间序列更冗余和分离。在从不同的配置及时改变他们的网络方面，患者不如对照组灵活，并且以一种效率较低的方式探索可能状态的整个景观。这些变化与患者接受的抗精神病药物剂量有关。我们在治疗前后扫描的抗精神病药物初治FEP样本中复制了与抗精神病药物的关系。结论：我们得出结论，精神病与大脑动态功能连接的暂时紊乱有关，这与抗精神病药物的使用有关。
BACKGROUND AND HYPOTHESIS Abnormal functional connectivity between brain regions is a consistent finding in schizophrenia, including functional magnetic resonance imaging (fMRI) studies. Recent studies have highlighted that connectivity changes in time in healthy subjects. We here examined the temporal changes in functional connectivity in patients with a first episode of psychosis (FEP). Specifically, we analyzed the temporal order in which whole-brain organization states were visited. STUDY DESIGN Two case-control studies, including in each sample a subgroup scanned a second time after treatment. Chilean sample included 79 patients with a FEP and 83 healthy controls. Mexican sample included 21 antipsychotic-naïve FEP patients and 15 healthy controls. Characteristics of the temporal trajectories between whole-brain functional connectivity meta-states were examined via resting-state functional MRI using elements of network science. We compared the cohorts of cases and controls and explored their differences as well as potential associations with symptoms, cognition, and antipsychotic medication doses. STUDY RESULTS We found that the temporal sequence in which patients' brain dynamics visited the different states was more redundant and segregated. Patients were less flexible than controls in changing their network in time from different configurations, and explored the whole landscape of possible states in a less efficient way. These changes were related to the dose of antipsychotics the patients were receiving. We replicated the relationship with antipsychotic medication in the antipsychotic-naïve FEP sample scanned before and after treatment. CONCLUSIONS We conclude that psychosis is related to a temporal disorganization of the brain's dynamic functional connectivity, and this is associated with antipsychotic medication use.