ENVIRONMENTAL TOXICANT EXPOSURE AND THE EPIGENOME
ENVIRONMENTAL TOXICANT EXPOSURE AND THE EPIGENOME
复制标题
DOI：
10.1016/b978-0-444-59389-4.00004-5
复制
发表时间：
2012-01-01
期刊：
影响因子：
--
通讯作者：
Fry, Rebecca C.
中科院分区：
文献类型：
--
作者：
Bailey, Kathryn A.;Fry, Rebecca C.
表观遗传修饰（例如，DNA甲基化、组蛋白翻译后修饰和microRNA）通过控制基因表达在胚胎发育、组织分化和疾病发展中起着至关重要的作用。越来越多的证据表明，这种改变会极大地影响人类健康，可能与环境毒物相关疾病特别相关。在本章中，我们讨论了几种高优先级毒物及其与表观遗传修饰的关系。对于这些毒物中的每一种，表观遗传改变被认为在其相关的有害影响中发挥重要作用。具体来说，我们专注于代表有毒物质从三个不同的化学类别：致癌金属，内分泌干扰物，和多环芳烃。我们详细介绍了目前对与暴露于这些毒物相关的表观遗传改变的理解，以及这些改变如何导致有害的健康影响。
Epigenetic modifications (e.g., DNA methylation, histone post-translational modifications, and microRNAs) play a vital role in embryonic development, tissue differentiation, and disease development through control of gene expression. There is increasing evidence that such alterations can greatly impact human health and may be particularly relevant for environmental toxicant-associated diseases. In this chapter, we discuss several high-priority toxicants and their relationship to epigenetic modifications. For each of these toxicants, epigenetic alterations are believed to play an important role in their associated detrimental effects. Specifically, we focus on representative toxicants from three different chemical classes: carcinogenic metals, endocrine disruptors, and polycyclic aromatic hydrocarbons. We detail the current understanding of epigenetic alterations associated with exposure to each of these toxicants as well as how these alterations may contribute to deleterious health effects.