Effects of corticosteroids on noninvasive biomarkers of inflammation in asthma and chronic obstructive pulmonary disease.
Effects of corticosteroids on noninvasive biomarkers of inflammation in asthma and chronic obstructive pulmonary disease.
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DOI：
10.1513/pats.200402-011ms
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发表时间：
2004-01-01
期刊：
影响因子：
--
通讯作者：
Barnes, Peter J
中科院分区：
文献类型：
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作者：
Kharitonov, Sergei A;Barnes, Peter J
呼出气分析可用于量化呼吸道中的炎症和氧化应激，用于气道疾病的鉴别诊断，以及用于治疗的监测。最大的进展是呼出气一氧化氮（NO）的标准化测量。支气管NO在哮喘中增加，与其他炎症标志物相关，并通过皮质类固醇和抗白三烯治疗减少。慢性阻塞性肺疾病（COPD）患者肺泡NO增加，反映了疾病的严重程度和进展。在哮喘和COPD中呼出的一氧化碳和乙烷都增加。在患有炎性肺病的患者的呼出气冷凝物中发现8-异前列烷、过氧化氢、亚硝酸盐和硝基酪氨酸的浓度增加。还发现脂质介质水平升高，其模式取决于疾病过程的性质。其他生物标志物是呼出气温度，其在哮喘中升高而在COPD中降低，以及支气管血流。更小和更灵敏的分析仪可能会扩大呼出气分析的鉴别价值，新技术将可用于诊断和监测家庭实践和家庭环境中的呼吸系统疾病。
Exhaled breath analysis may be used to quantify inflammation and oxidative stress in the respiratory tract, in the differential diagnosis of airway diseases, and in the monitoring of therapy. The greatest progress has been made with standardized measurement of exhaled nitric oxide (NO). Bronchial NO is increased in asthma, correlated with other markers of inflammation, and reduced by treatment with corticosteroids and antileukotrienes. Alveolar NO is increased in chronic obstructive pulmonary disease (COPD), reflecting disease severity and progression. Exhaled carbon monoxide and ethane are increased in both asthma and COPD. Increased concentrations of 8-isoprostane, hydrogen peroxide, nitrite, and nitrotyrosine are found in exhaled breath condensate from patients with inflammatory lung diseases. Increased levels of lipid mediators are also found, and the pattern depends on the nature of the disease process. Additional biomarkers are exhaled breath temperature, which is elevated in asthma and reduced in COPD, and bronchial blood flow. It is likely that smaller and more sensitive analyzers will extend the discriminatory value of exhaled breath analysis and that new techniques will become available to diagnose and monitor respiratory diseases in the family practice and home settings.