Activation and inhibition of olfactory bulb neurones by anterior commissure volleys in the rabbit.
Activation and inhibition of olfactory bulb neurones by anterior commissure volleys in the rabbit.
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兔子前连合齐射对嗅球神经元的激活和抑制。
DOI：
10.1113/jphysiol.1978.sp012363
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发表时间：
1978
期刊：
影响因子：
--
通讯作者：
S. Takagi
中科院分区：
文献类型：
--
作者：
K. Mori;S. Takagi
1.在兔嗅球中，对记录到的二尖瓣细胞和颗粒细胞层神经元的细胞内电位进行了分析。细胞)，以及前连合(A.C.)引起的嗅球细胞外场电位。刺激。2.大多数二尖瓣细胞记录显示I.P.P.，其潜伏期为7-11毫秒。刺激。这些I.P.类似于侧嗅束诱发的I.P.刺激使它们对内部施加的电流敏感，并且在施加超极化电流时表现出不对称的反转。3.在AC中截击。在类型1 g.c.l.中引出的e.p.s.p.s。从二尖瓣细胞的I.p.s.p.s分析推测其特征与抑制性神经元间的特征一致。有人认为，这些类型1g.c.l。在二尖瓣细胞中，细胞可能是共同的抑制性神经元(可能是颗粒细胞)，既介导AC诱发的I.P.又介导L.O.诱发的I.P.4.空调。在二尖瓣细胞中，刺激抑制了测试1o.t.诱发的i.p.p.ps，而在1型g.c.l中，则抑制了测试.o.t.诱发的e.p.p.ps。细胞。这些观察结果与L.O.诱发的I.P.主要由二尖瓣细胞树突与颗粒细胞外周突起之间的树-树相互突触所介导的假说相一致。5.结果与控制嗅球二尖瓣细胞活动的抑制机制有关。
1. In the rabbit olfactory bulb, analysis has been carried out on intracellular potentials recorded from mitral cells and neurones in the granule cell layer (g.c.l. cells) in addition to the extracellular field potentials in the olfactory bulb elicited by anterior commissure (a.c.) stimulation. 2. Most mitral cell recordings showed i.p.s.p.s with latency of 7‐11 msec following a.c. stimulation. These i.p.s.p.s were similar to those evoked by lateral olfactory tract (l.o.t.) stimulation in their sensitivity to internally applied current and showed asymmetrical reversal during application of the hyperpolarizing current. 3. Volleys in the a.c. elicited e.p.s.p.s in type 1 g.c.l. cells whose characteristics were in agreement with those of inhibitory interneurones inferred from the analyses of mitral cell i.p.s.p.s. It has been suggested that these type 1 g.c.l. cells may be the common inhibitory interneurones (presumably granule cells) mediating both a.c.‐evoked and l.o.t.‐evoked i.p.s.p.s in mitral cells. 4. Conditioning a.c. stimulation depressed the test l.o.t.‐evoked i.p.s.p.s in mitral cells and test l.o.t.‐evoked e.p.s.p.s in type 1 g.c.l. cells. These observations are in good agreement with the hypothesis that l.o.t.‐evoked i.p.s.p.s are mainly mediated by the dendrodendritic reciprocal synapses between mitral cell dendrites and peripheral processes of granule cells. 5. The results are discussed in relation to the inhibitory mechanisms controlling mitral cell activity in the olfactory bulb.