PLASMA-LIPID, LIPOPROTEIN CHOLESTEROL, AND APOPROTEIN DISTRIBUTIONS IN SELECTED UNITED-STATES COMMUNITIES - THE ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC) STUDY
PLASMA-LIPID, LIPOPROTEIN CHOLESTEROL, AND APOPROTEIN DISTRIBUTIONS IN SELECTED UNITED-STATES COMMUNITIES - THE ATHEROSCLEROSIS RISK IN COMMUNITIES (ARIC) STUDY
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DOI：
10.1161/01.atv.13.8.1139
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发表时间：
1993-08-01
期刊：
影响因子：
--
通讯作者：
PATSCH, W
中科院分区：
文献类型：
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作者：
BROWN, SA;HUTCHINSON, R;PATSCH, W
介绍了社区动脉粥样硬化风险 (ARIC) 研究中 14 524 名 45 至 64 岁的女性和男性黑人和白人参与者的血浆脂质、脂蛋白和脱辅基蛋白的分布。所有样本均在中心实验室进行分析。所有年龄段的平均总胆固醇水平随着年龄的增加而增加，女性从 204 至 229 mg/dL (12%)，男性从 208 至 213 mg/dL (2%)。女性的甘油三酯水平随着年龄的增长而增加，男性的甘油三酯水平保持稳定，白人的甘油三酯水平高于黑人。黑人和白人女性的高密度脂蛋白 (HDL) 胆固醇水平（范围为 57 至 59 mg/dL）高于黑人男性（49 至 52 mg/dL）或白人男性（42 至 43 mg/dL）。对于所有种族/性别组，与 HDL 相关的胆固醇以相对恒定的比例分布在 HDL3（70% 至 76%）和 HDL2（24% 至 30%）之间。黑人（14.7%）和白人（17.1%）女性以及黑人（4.4%）和白人（3.7%）男性的低密度脂蛋白（LDL）胆固醇水平随着年龄的增长而增加；超过 50% 的参与者 LDL 胆固醇水平 > 130 mg/dL。脱辅基蛋白 A-1 和 B 水平分别与 HDL 胆固醇和 LDL 胆固醇水平具有相同的趋势。黑人的脂蛋白(a) [Lp(a)] 水平是白人的两倍，并且每个种族的女性 Lp(a) 水平均高于男性 Lp(a) 水平。更年期与总胆固醇、LDL 胆固醇、脱辅基蛋白 B 和 Lp(a) 水平升高相关，绝经后受试者使用激素替代药物与 HDL 胆固醇、甘油三酯和脱辅基蛋白 A-1 水平升高以及 LDL 胆固醇、脱辅基蛋白 B 和 Lp(a) 水平降低相关。
The distributions of plasma lipids, lipoproteins, and apoproteins of 14 524 female and male black and white participants 45 to 64 years old in the Atherosclerosis Risk in Communities (ARIC) Study are presented. All specimens were analyzed at a central laboratory. Mean total cholesterol levels increased with increasing age across all ages from 204 to 229 mg/dL (12%) in women and from 208 to 213 mg/dL (2%) in men. Triglyceride levels increased with age in women, remained stable in men, and were higher in whites than blacks. High-density lipoprotein (HDL) cholesterol levels were higher in black and white women (range, 57 to 59 mg/dL) compared with black men (49 to 52 mg/dL) or white men (42 to 43 mg/dL). Cholesterol associated with HDL was distributed in a relatively constant proportion between HDL3 (70% to 76%) and HDL2 (24% to 30%) for all race/sex groups. Low-density lipoprotein (LDL) cholesterol levels increased with age in black (14.7%) and white (17.1%) women and in black (4.4%) and white (3.7%) men; more than 50% of all participants had LDL cholesterol levels > 130 mg/dL. Apoprotein A-1 and B levels followed the same trends as HDL cholesterol and LDL cholesterol levels, respectively. Lipoprotein(a) [Lp(a)] levels were twice as high in blacks as in whites, and women's Lp(a) levels were higher than men's Lp(a) levels for each race. Menopause was associated with elevated total cholesterol, LDL cholesterol, apoprotein B, and Lp(a) levels, and hormone replacement medication use in postmenopausal subjects was associated with higher HDL cholesterol, triglyceride, and apoprotein A-1 levels and lower LDL cholesterol, apoprotein B, and Lp(a) levels.