MEMORY DYSFUNCTION IN PANIC DISORDER: AN INVESTIGATION OF THE ROLE OF CHRONIC BENZODIAZEPINE USE
MEMORY DYSFUNCTION IN PANIC DISORDER: AN INVESTIGATION OF THE ROLE OF CHRONIC BENZODIAZEPINE USE
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DOI：
10.1002/da.20891
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发表时间：
2011-11-01
影响因子：
7.4
通讯作者：
Otto, Michael W.
中科院分区：
文献类型：
--
作者：
Deckersbach, Thilo;Moshier, Samantha J.;Otto, Michael W.
背景：长期服用苯二氮卓类药物对神经认知影响的研究因神经认知缺陷的存在而混乱，这些缺陷表征了服用这些药物的临床条件。同样，对焦虑症的神经认知影响的研究也因纳入长期服用苯二氮卓类药物的患者而变得混乱。这项研究旨在梳理长期使用苯二氮卓类药物和惊恐障碍(PD)对记忆和视觉建构能力的潜在混杂影响。方法：对20例长期服用苯二氮卓类药物的帕金森病患者和20例不服用苯二氮卓类药物的帕金森病患者和20例年龄、教育程度和性别相匹配的正常对照组进行一系列神经心理测试，评估短期记忆、情景记忆、语义记忆和视觉建构能力。结果：非苯二氮类惊恐患者的非言语短时和非言语情景长时记忆和视觉建构能力相对受损，而言语短时和言语情景记忆和语义记忆被保留。只有有限的证据表明，在长期服用苯二氮卓类药物的帕金森病患者中存在更明显的损害。结论：本研究提供的证据表明，帕金森病患者的特征是非言语记忆和视觉建构能力的相对损害，与苯二氮卓类药物的使用无关。尽管如此，我们发现有证据表明，苯二氮类药物的慢性治疗与这一领域中特定的相对损害的加剧有关。对这些缺陷的记录提出了关于帕金森病神经认知障碍的更广泛的病因以及它对日常功能的影响的问题。抑郁与焦虑28：999-1007,2011。(C)2011年威利期刊公司。
Background: Studies of the neurocognitive effects of long-term benzodiazepine use have been confounded by the presence of neurocognitive deficits characterizing the clinical conditions for which these medications are taken. Similarly, studies of the neurocognitive effects of anxiety disorders have been confounded by the inclusion of chronically benzodiazepine-medicated patients. This study was designed to tease apart the potentially confounding effects of long-term benzodiazepine use and panic disorder (PD) on memory and visuoconstructive abilities. Methods: Twenty chronically benzodiazepine-medicated and 20 benzodiazepine-free patients with PD with agoraphobia were compared with a group of 20 normal control participants, group-matched for age, education, and gender on a battery of neuropsychological tests assessing short-term, episodic long-term, and semantic memory, as well as visuoconstructive abilities. Results: Results indicated that benzodiazepine-free panic patients were relatively impaired in nonverbal short-term and nonverbal episodic long-term memory and visuoconstructive abilities, whereas verbal short-term and verbal episodic memory and semantic memory were preserved. Only limited evidence was found for more pronounced impairments in chronically benzodiazepine-medicated PD patients. Conclusions: This study provides evidence that patients with PD are characterized by relative impairments in nonverbal memory and visuoconstructive abilities, independent of benzodiazepine use. Nonetheless, we found evidence that chronic treatment with benzodiazepines is associated with intensification of select relative impairments in this realm. Documentation of these deficits raises questions about the broader etiology of neurocognitive impairment in PD as well as its impact on daily functioning. Depression and Anxiety 28: 999-1007, 2011. (C) 2011 Wiley Periodicals, Inc.