NEUROANATOMICAL PATHWAYS LINKING VISION AND OLFACTION IN MAMMALS
NEUROANATOMICAL PATHWAYS LINKING VISION AND OLFACTION IN MAMMALS
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DOI：
10.1016/0306-4530(94)90046-9
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发表时间：
1994-01-01
影响因子：
3.7
通讯作者：
MAGNIN, M
中科院分区：
文献类型：
--
作者：
COOPER, HM;PARVOPASSU, F;MAGNIN, M
视网膜投射到几个端脑结构已被证明在眼内注射氚化氨基酸和霍乱毒素亚基-B结合辣根过氧化物酶后，在广泛的哺乳动物物种。由于这些地区也受到嗅觉纤维的支配，我们研究了会聚投影的分布，同时注射不同的顺行示踪剂在眼睛和嗅球。在梨状皮质、嗅结节、内侧杏仁核皮质区、外侧下丘脑和终纹床核中观察到来自视网膜和嗅球的会聚投射。少数视网膜纤维还侵犯外侧嗅束核、副嗅球床核和Broca斜角带。在内侧杏仁核，床核或外侧下丘脑的逆行示踪剂注射表明，视觉嗅觉会聚主要涉及来自副嗅球的投射，并在较小程度上从主嗅球的腹内侧区域。在视网膜中发现不到20个视网膜端脑神经节细胞，主要位于注射部位的对侧。神经节细胞中等大小，有两个细长的相对树突。这些视网膜和嗅觉的预测可以提供一个解剖基板的促性腺激素水平的调制和嗅觉的影响光介导的节奏有关的生殖生理。
Retinal projections to several telencephalic structures have been demonstrated in a wide range of mammalian species following intraocular injections of tritiated amino acids and cholera toxin subunit-B conjugated to horseradish peroxidase. Since these regions are also innervated by olfactory fibers, we investigated the distribution of convergent projections using simultaneous injections of different anterograde tracers in the eye and olfactory bulbs. Convergent projections from the retina and from the olfactory bulbs were observed in the piriform cortex, olfactory tubercle, the cortical region of the medial amygdala, lateral hypothalamus, and the bed nucleus of the stria terminalis. A few retinal fibers also invade the nucleus of the lateral olfactory tract, the bed nucleus of the accessory olfactory bulb and the diagonal band of Broca. Injections of retrograde tracers in the medial amygdala, the bed nucleus or the lateral hypothalamus shows that the visuo-olfactory convergence mainly involves projections originating from the accessory olfactory bulb, and to a lesser extent from the ventromedial region of the main olfactory bulb. Fewer than 20 retinotelencephalic ganglion cells were identified in the retina, mainly located contralateral to the injection site. Ganglion cells were medium sized and possessed two long slender opposing dendrites. These retinal and olfactory projections could provide an anatomical substrate for the modulation of gonadotropin hormone levels and the olfactory influence on light mediated rhythms related to reproductive physiology.