An event-related potential examination of contour integration deficits in schizophrenia
An event-related potential examination of contour integration deficits in schizophrenia
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DOI：
10.3389/fpsyg.2013.00132
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发表时间：
2013-03-21
影响因子：
3.8
通讯作者：
Sehatpour, Pejman
中科院分区：
文献类型：
--
作者：
Butler, Pamela D.;Abeles, Ilana Y.;Sehatpour, Pejman
知觉组织是指整合刺激片段以形成整个边缘、部分或物体的表征的能力，在精神分裂症中受损。一个轮廓整合范例，涉及检测的一组Gabor补丁形成一个椭圆形的轮廓指向右或左嵌入在一个领域的随机取向的Gabor，已被开发用于精神分裂症的临床试验。本研究的目的是评估的早期和后期阶段的处理轮廓整合赤字的贡献，以及开发一个事件相关电位（ERP）模拟这项任务。21名精神分裂症患者和28名对照参与。形成轮廓的Gabor元素被赋予低或高程度的方向抖动，使得识别轮廓指向的方向变得容易或困难。ERP结果显示更大的负峰在类似于165（N1分量）和类似于270毫秒的低抖动与高抖动的轮廓，与抖动条件之间的差异更大，在270毫秒。这后来的ERP组件以前被称为N-cl关闭负性。源定位确定了NCL在枕外侧目标识别区。与对照组相比，患者的N-cl显著降低，但N1没有降低，这与识别轮廓的行为能力受损有关。此外，在120 ms（称为N120）附近发现了一个较早的负峰，该峰区分了抖动条件，具有背流源，并且在患者和对照之间存在差异。患者还表现出背流感觉P1成分的缺陷。这些结果是在雅阁与分布式电路的损伤，有助于知觉组织赤字，并提供了一个ERP模拟的行为轮廓整合任务。
Perceptual organization, which refers to the ability to integrate fragments of stimuli to form a representation of a whole edge, part, or object, is impaired in schizophrenia. A contour integration paradigm, involving detection of a set of Gabor patches forming an oval contour pointing to the right or left embedded in a field of randomly oriented Gabors, has been developed for use in clinical trials of schizophrenia. The purpose of the present study was to assess contributions of early and later stages of processing to deficits in contour integration, as well as to develop an event-related potential (ERP) analog of this task. Twenty-one patients with schizophrenia and 28 controls participated. The Gabor elements forming the contours were given a low or high degree of orientational jitter, making it either easy or difficult to identify the direction in which the contour was pointing. ERP results showed greater negative peaks at similar to 165 (N1 component) and similar to 270 ms for the low-jitter versus the high-jitter contours, with a much greater difference between jitter conditions at 270 ms. This later ERP component was previously termed N-cl for closure negativity. Source localization identified the Ncl in the lateral occipital object recognition area. Patients showed a significant decrease in the N-cl, but not N1, compared to controls, and this was associated with impaired behavioral ability to identify contours. In addition, an earlier negative peak was found at similar to 120 ms (termed N120) that differentiated jitter conditions, had a dorsal stream source, and differed between patients and controls. Patients also showed a deficit in the dorsal stream sensory P1 component. These results are in accord with impairments in distributed circuitry contributing to perceptual organization deficits and provide an ERP analog to the behavioral contour integration task.