Histological evaluation of patients with gastritis at high risk of developing gastric cancer using a conventional index
Histological evaluation of patients with gastritis at high risk of developing gastric cancer using a conventional index
复制标题
DOI：
10.1016/j.prp.2011.03.001
复制
发表时间：
2011-01-01
影响因子：
2.8
通讯作者：
Haruma, Ken
中科院分区：
文献类型：
--
作者：
Tanaka, Aki;Kamada, Tomoari;Haruma, Ken
尽管胃癌（GCa）与幽门螺杆菌感染密切相关，但只有一些幽门螺杆菌阳性受试者才会患上胃癌。本研究的目的是通过评估患有和不患有GCa的患者的非含癌粘膜的组织病理学结果来识别具有发展GCa高风险的幽门螺杆菌阳性受试者。受试者包括35名弥漫型胃癌（D-GCa）患者、55名肠型胃癌（I-GCa）患者和99名不患有GCa的幽门螺杆菌阳性对照患者。两个标本取自胃窦大弯和中体。使用更新的悉尼系统评估组织病理学分级，并使用改良的梅宁胃癌风险指数（GCRI）评估GCa风险。在幽门螺杆菌阳性对照中，98.0%（97/99）患有胃体胃炎，78.8%（78/99）患有胃体萎缩性胃炎。 D-GCa (5.514 +/- 2.03) 和 I-GCa (6.836 +/- 2.08) 组的平均 GCRI 显着高于幽门螺杆菌阳性对照 (4.071 +/- 2.07；p = 0.0005，p < 0.0001)。此外，I-GCa 组的平均 GCRI 显着高于 D-GCa 组 (p < 0.005)。 GCa 受试者的 GCRI 阳性率显着高于幽门螺杆菌阳性对照者（D-GCa：p < 0.005，I-GCa：p < 0.0001）。许多幽门螺杆菌阳性的日本人仍然具有患胃癌的高风险。然而，使用简单的 GCRI 可以检测到发生 GCa（不仅是肠型而且还包括弥漫型）高风险的幽门螺杆菌阳性患者。 (C) 2011 爱思唯尔有限公司。版权所有。
Although gastric cancer (GCa) is strongly associated with Helicobacter pylori infection, only some H. pylori-positive subjects develop gastric cancer. The aim of this study is to identify H. pylori-positive subjects at high risk of developing GCa by assessment of the histopathological findings in the non-cancer-containing mucosa of patients with and without GCa.The subjects were 35 patients with diffuse-type gastric cancer (D-GCa), 55 with intestinal-type gastric cancer (I-GCa), and 99 H. pylori-positive controls without GCa. Two specimens were taken from the greater curvature of the antrum and the middle body. Histopathological gradings were evaluated using the updated Sydney System, and the risk of GCa was evaluated using a modified Meining's gastric cancer risk index (GCRI). Among the H. pylori-positive controls, corpus gastritis was seen in 98.0% (97/99) and corpus atrophic gastritis in 78.8% (78/99). The mean GCRI for the D-GCa (5.514 +/- 2.03) and I-GCa (6.836 +/- 2.08) groups was significantly greater than that for the H. pylori-positive controls (4.071 +/- 2.07; p = 0.0005, p < 0.0001). In addition, the mean GCRI for the I-GCa group was significantly greater than that for the D-GCa group (p < 0.005). The GCRI-positive rate was significantly higher in subjects with GCa than in H. pylori-positive controls (D-GCa: p < 0.005, I-GCa: p < 0.0001).Many H. pylori-positive Japanese still carry a high risk for gastric cancer. However, H. pylori-positive patients at high risk of developing GCa (not only intestinal-type but also diffuse-type) may be detected using a simple GCRI. (C) 2011 Elsevier GmbH. All rights reserved.