SIGNIFICANCE OF POSITIVE CROSSMATCH TEST IN KIDNEY TRANSPLANTATION
SIGNIFICANCE OF POSITIVE CROSSMATCH TEST IN KIDNEY TRANSPLANTATION
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DOI：
10.1056/nejm196904032801401
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发表时间：
1969-01-01
影响因子：
158.5
通讯作者：
TERASAKI, PI
中科院分区：
文献类型：
--
作者：
PATEL, R;TERASAKI, PI
在225例肾移植患者中，对预期肾移植供体的淋巴细胞与预期受体的血清进行交叉配型试验，结果显示，交叉配型阴性的195例患者中有8例未能立即发挥功能，而交叉配型阳性的30例患者中有24例未能立即发挥功能（p <0.001）。在具有较高抗体风险的患者中，如经产女性和接受二次移植的患者，立即失败的发生率显著较高。这种影响并非非特异性的，因为来自无关供者的移植比来自相关供者的移植更容易立即失败。相关供体中相应的阳性交叉配型频率也较低。预先形成的针对供体的细胞毒性抗体的存在似乎是移植的强烈禁忌症。
Crossmatch tests of the prospective kidney-transplant donor's lymphocytes with the serum of the prospective recipient in 225 transplants showed that eight of 195 with negative crossmatch failed to function immediately, in contrast to 24 of 30 with positive crossmatch (p less than 0.001). Immediate failure occurred in significantly higher numbers among patients with a higher risk of having antibodies, such as multiparous females and patients receiving secondary transplants. The effect was not a nonspecific one, for more immediate failures occurred among transplants from unrelated than among those from related donors. The corresponding frequency of positive crossmatch was also lower among related donors. The presence of preformed cytotoxic antibodies against the donor appears to be a strong contraindication for transplantation.