Normalization of blood pressure and renal vascular resistance in SHR with a membrane-permeable superoxide dismutase mimetic - Role of nitric oxide

Normalization of blood pressure and renal vascular resistance in SHR with a membrane-permeable superoxide dismutase mimetic - Role of nitric oxide
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DOI：
10.1161/01.hyp.32.1.59
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发表时间：
1998-07-01
期刊：
HYPERTENSION
影响因子：
8.3
通讯作者：
Wilcox, CS
Wilcox, CS
中科院分区：
医学1区
文献类型：
--
作者：
Schnackenberg, CG;Welch, WJ;Wilcox, CS

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自发性高血压大鼠（SHR）血管壁中超氧自由基（O-2（-））增加，其阻断增强内皮依赖性血管舒张。本研究旨在探讨O-2（-）在自发性高血压（SHR）高血压和肾血管收缩中的作用及其与一氧化氮（NO）的相互作用。与Wistar-Kyoto大鼠（WKY; n=6）相比，SHR（n=6）的基线平均动脉压（MAP）和肾血管阻力显著升高（145+/-4 vs 118+/-4 mm Hg，P
Superoxide radical (O-2(-)) is increased in the vessel wall of spontaneously hypertensive rats (SHR) where its blockade potentiates endothelium-dependent vasodilation. The purpose of this study was to determine the role of O-2(-) in the hypertension and renal vasoconstriction of SHR and its interaction with nitric oxide (NO). Baseline mean arterial pressure (MAP) and renal vascular resistance were markedly elevated in SHR (n=6) compared with Wistar-Kyoto rats (WKY; n=6) (145+/-4 versus 118+/-4 mm Hg, P