Chronic Myeloid Leukemia following Chemotherapy with 5′-deoxy-5-fluorouridine for Gastric Cancer
Chronic Myeloid Leukemia following Chemotherapy with 5′-deoxy-5-fluorouridine for Gastric Cancer
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DOI：
10.2169/internalmedicine.47.1072
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发表时间：
2008-01-01
影响因子：
1.2
通讯作者：
Ezaki, Kohji
中科院分区：
文献类型：
--
作者：
Tsuzuki, Motohiro;Handa, Kousuke;Ezaki, Kohji
我们在此报告一个非常罕见的慢性粒细胞白血病（CML）病例，长期使用5 ′-脱氧-5-氟尿苷（5 ′-DFUR）治疗胃癌。一名69岁的男子被诊断为慢性粒细胞白血病的慢性期。六年前，他因胃癌接受了根治性胃次全切除术，随后接受了口服抗代谢物5 '-DFUR作为辅助化疗6年。他接受伊马替尼治疗，并在治疗开始后10个月获得主要分子学缓解。这是第一例报告的5 '-DFUR治疗后治疗相关的CML病例。
We report here a very rare case of chronic myeloid leukemia (CML) following long-term chemotherapy with 5'-deoxy-5-fluorouridine (5'-DFUR) for gastric cancer. A 69-year-old man was diagnosed with the chronic phase of CML. Six years previously, he underwent radical subtotal gastrectomy for gastric cancer, and was subsequently treated with oral anti-metabolite 5'-DFUR as adjuvant chemotherapy for 6 years. He was placed on imatinib therapy, and achieved a major molecular response 10 months after the initiation of therapy. This is the first reported case of therapy-related CML following 5'-DFUR treatment.