Muscle Strength and BMI as Predictors of Major Mobility Disability in the Lifestyle Interventions and Independence for Elders Pilot (LIFE-P)
Muscle Strength and BMI as Predictors of Major Mobility Disability in the Lifestyle Interventions and Independence for Elders Pilot (LIFE-P)
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DOI：
10.1093/gerona/glr158
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发表时间：
2011-12-01
影响因子：
5.1
通讯作者：
Pahor, Marco
中科院分区：
文献类型：
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作者：
Marsh, Anthony P.;Rejeski, W. Jack;Pahor, Marco
肌肉无力和肥胖是越来越多的老年人面临的两大威胁。到目前为止，还没有研究检验力量和身体质量指数（BMI）与事件发生率之间的关系，这是一种广泛使用的主要行动不便的表现衡量标准。本研究是对一项随机对照试验的二次分析，在该试验中，久坐功能受限的参与者（70-89岁，短体能表现电池< 9）在基线时能够完成400米步行测试，被随机分配到身体活动或健康教育干预组，并每6个月重新评估一次主要行动障碍，最长可达18个月。我们评估了基线握力和BMI是否能预测在15分钟或更短时间内完成400米步行测试的失败（主要行动障碍）。在基线测量的N = 406名参与者中，低握力与发生主要行动障碍的风险增加相关，有或没有协变量调整（p < 0.01）：握力最低与高性别特异性四分位数的风险比（95%置信区间）为6.11（2.24-16.66）。我们观察到基线BMI与发生主要行动障碍的风险之间呈u型关系，因此BMI在25-29 kg/m(2)之间的参与者的风险大约是BMI低于25或30 kg/m(2)或更高的参与者的一半（在完全调整分析中p = 0.04）。我们的数据强调了肌肉无力、低BMI和肥胖作为老年人主要行动障碍的危险因素的重要性。超重可能对主要的行动障碍有保护作用。
Muscle weakness and obesity are two significant threats to mobility facing the increasing number of older adults. To date, there are no studies that have examined the association of strength and body mass index (BMI) on event rates on a widely used performance measure of major mobility disability.This study was a secondary analysis of a randomized controlled trial in which sedentary functionally limited participants (70-89 years, Short Physical Performance Battery < 9) who were able to complete a 400-m walk test at baseline were randomized to a physical activity or health education intervention and reassessed for major mobility disability every 6 months for up to 18 months. We evaluated whether baseline grip strength and BMI predicted failure to complete the 400-m walk test in 15 minutes or less (major mobility disability).Among N = 406 participants with baseline measures, lower grip strength was associated with an increased risk for developing major mobility disability, with and without covariate adjustment (p < .01): The hazard ratio (95% confidence interval) for the lowest versus high sex-specific quartile of grip strength was 6.11 (2.24-16.66). We observed a U-shaped relationship between baseline BMI and the risk of developing major mobility disability, such that the risk for participants with a BMI of 25-29 kg/m(2) was approximately half that of participants with BMI less than 25 or 30 kg/m(2) or more (p = .04 in fully adjusted analyses).Our data highlight the importance of muscle weakness, low BMI, and obesity as risk factors for major mobility disability in older adults. Being overweight may be protective for major mobility disability.