Electrically Actuatable Smart Nanoporous Membrane for Pulsatile Drug Release
Electrically Actuatable Smart Nanoporous Membrane for Pulsatile Drug Release
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DOI：
10.1021/nl104329y
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发表时间：
2011-03-01
期刊：
影响因子：
10.8
通讯作者：
Kim, Jin Kon
中科院分区：
文献类型：
--
作者：
Jeon, Gumhye;Yang, Seung Yun;Kim, Jin Kon
报道了在氧化铝膜上部电聚合聚吡咯掺杂十二烷基苯磺酸阴离子(PPy/DBS)制备电响应性纳米孔膜的方法。该膜具有规则的孔径和很高的孔密度。利用PPy/DBS的体积随电化学状态变化较大的特点，对其孔径进行了电学测量。用原位原子力显微镜和原位通量测量实验证实了气孔的驱动作用。我们还通过使用荧光标记的蛋白质作为模型药物，成功地展示了脉动(或按需)药物释放。该膜切换时间快(<10 S)，药物通量大，可用于急诊、按需给药的心绞痛、偏头痛、激素相关性疾病和代谢综合征的急诊治疗。
We report on the fabrication of electrically responsive nanoporous membrane based on polypyrrole doped with dodecylbenzenesulfonate anion (PPy/DBS) that was electropolymerized on the upper part of anodized aluminum oxide membrane. The membrane has regular pore size and very high pore density. Utilizing a large volume change of PPy/DBS depending on electrochemical state, the pore size was acutated electrically. The actuation of the pores was experimentally confirmed by in situ atomic force microscopy and in situ flux measurement. We also demonstrated successfully pulsatile (or on-demand) drug release by using fluorescently labeled protein as a model drug. Because of a fast switching time (less than 10 s) and high flux of the drugs, this membrane could be used for emergency therapy of angina pectoris and migraine, which requires acute and on-demand drug delivery, and hormonerelated disease and metabolic syndrome.