Reprogramming DNA-directed reactions on the basis of a DNA conformational change
Reprogramming DNA-directed reactions on the basis of a DNA conformational change
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DOI：
10.1021/ja045718j
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发表时间：
2004-10-20
影响因子：
15
通讯作者：
Mao, C
中科院分区：
文献类型：
--
作者：
Chen, Y;Mao, C
基于−双链三链转换，发展了一种在两个完全相同的试剂之间切换化学反应的策略。作为对溶液pH变化的响应，DNA复合体改变其构象并重新定位与DNA链连接的化学试剂。结果，化学反应被重新编程。这一策略有望应用于复杂的化学合成。
A strategy has been developed for switching chemical reactions between two identical reagents on the basis of DNA duplex−triplex transition. In response to the change of solution pH, a DNA complex changes its conformation and repositions chemical reagents that are conjugated with DNA strands. As a result, chemical reactions are reprogrammed. This strategy is expected to be applicable to sophisticated chemical syntheses.