Sublingual Nitroglycerin Administration in Coronary Computed Tomography Angiography: a Systematic Review.
Sublingual Nitroglycerin Administration in Coronary Computed Tomography Angiography: a Systematic Review.
复制标题
冠状动脉断层扫描血管造影的舌下硝酸甘油给药：系统评价。
DOI：
10.1007/s00330-015-3791-3
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发表时间：
2015-12
影响因子：
5.9
通讯作者：
Hoffmann U
中科院分区：
文献类型：
--
作者：
Takx RA;Suchá D;Park J;Leiner T;Hoffmann U
系统研究舌下含服硝酸甘油对冠状动脉直径、可评价节段数量、图像质量、心率和血压以及冠状动脉计算机断层扫描（CT）血管造影诊断准确性的影响。在PubMed、EMBASE和Web of Science中进行了系统检索。评价舌下含服硝酸甘油对冠状动脉直径、可评价节段、客观和主观图像质量、全身生理效应和诊断准确性的影响。由于结局指标报告的异质性，采用了叙述性综合。在确定的217项研究中，9项符合纳入标准：7项报告了硝酸甘油对冠状动脉直径的影响，6项报告了可评价的节段，4项报告了图像质量，5项报告了全身生理影响，2项报告了诊断准确性。舌下含服硝酸甘油改善了对更多冠状动脉节段的评价，特别是在较小的冠状动脉分支中，改善了图像质量并提高了诊断准确性。副作用轻微，无需医疗干预即可缓解。舌下含服硝酸甘油可改善冠状动脉直径、可评估节段数、图像质量和冠状动脉CT血管造影的诊断准确性，且无严重副作用或全身生理变化。·舌下含服硝酸甘油导致冠状动脉显著扩张。·硝酸甘油增加可评估的冠状动脉分支的数量。·图像质量在较小的冠状动脉分支中改善最多。·硝酸甘油可提高冠状动脉CT血管造影的诊断准确性。大多数副作用是轻微的，不需要医疗干预。
To systematically investigate the literature for the influence of sublingual nitroglycerin administration on coronary diameter, the number of evaluable segments, image quality, heart rate and blood pressure, and diagnostic accuracy of coronary computed tomography (CT) angiography. A systematic search was performed in PubMed, EMBASE and Web of Science. The studies were evaluated for the effect of sublingual nitroglycerin on coronary artery diameter, evaluable segments, objective and subjective image quality, systemic physiological effects and diagnostic accuracy. Due to the heterogeneous reporting of outcome measures, a narrative synthesis was applied. Of the 217 studies identified, nine met the inclusion criteria: seven reported on the effect of nitroglycerin on coronary artery diameter, six on evaluable segments, four on image quality, five on systemic physiological effects and two on diagnostic accuracy. Sublingual nitroglycerin administration resulted in an improved evaluation of more coronary segments, in particular, in smaller coronary branches, better image quality and improved diagnostic accuracy. Side effects were mild and were alleviated without medical intervention. Sublingual nitroglycerin improves the coronary diameter, the number of assessable segments, image quality and diagnostic accuracy of coronary CT angiography without major side effects or systemic physiological changes. • Sublingual nitroglycerin administration results in significant coronary artery dilatation. • Nitroglycerin increases the number of evaluable coronary branches. • Image quality is improved the most in smaller coronary branches. • Nitroglycerin increases the diagnostic accuracy of coronary CT angiography. • Most side effects are mild and do not require medical intervention.