Association of body mass index with exercise cardiopulmonary responses in lung function-matched patients with chronic obstructive pulmonary disease
Association of body mass index with exercise cardiopulmonary responses in lung function-matched patients with chronic obstructive pulmonary disease
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DOI：
10.1016/j.hrtlng.2012.02.010
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发表时间：
2012-07-01
期刊：
影响因子：
2.8
通讯作者：
Wu, Yao-Kuang
中科院分区：
文献类型：
--
作者：
Lan, Chou-Chin;Su, Chiu-Ping;Wu, Yao-Kuang
背景和目的：肺功能传统上被用来定义慢性阻塞性肺疾病(COPD)的严重程度。然而，这并不排除其他因素。目的：探讨体重指数(BMI)对1秒用力呼气容积(FEV1)匹配的COPD患者运动反应和生活质量的影响。对所有患者进行肺活量测定、心肺运动试验、呼吸肌力和圣乔治呼吸问卷(SGRQ)评定。结果：3组患者的基线特征和FEV1均值相似(P>；0.05)。体重不足患者的呼吸肌强度和SGRQ评分最低(P<；0.05)。在运动反应方面，低体重患者无氧阈值和峰值运动时的摄氧量最低，换气当量最高，氧脉搏最低(P<；0.05)。结论：低体重COPD患者呼吸肌力降低，运动能力受损，无氧代谢提前，机械通气无效，生活质量较差。
BACKGROUND AND OBJECTIVES: Lung function is traditionally used to define the severity of chronic obstructive pulmonary disease (COPD). However, this does not exclude other factors. This study investigated the influence of body mass index (BMI) on exercise responses and quality of life in patients with COPD matched for values of forced expiratory volume in 1 second (FEV1).METHODS: Underweight, normal-weight, and overweight patients with COPD, matched for FEV1, were studied. All patients were evaluated by spirometry, a cardiopulmonary exercise test, respiratory muscle strength, and, St. George's Respiratory Questionnaire (SGRQ).RESULTS: The baseline characteristics and mean FEV1 of the 3 groups were similar (P > .05). Respiratory muscle strengths and SGRQ scores were lowest in underweight patients (P < .05). In terms of exercise response, the lowest oxygen uptake at anaerobic threshold and peak exercise, the highest ventilatory equivalent, and the lowest oxygen pulse were evident in underweight patients (P < .05).CONCLUSIONS: Underweight patients with COPD had lower respiratory muscle strength, impaired exercise capacity, earlier anaerobic metabolism, ineffective ventilation, and poorer quality of life.