Epidemiology of pancreatic diseases in Luneburg county
Epidemiology of pancreatic diseases in Luneburg county
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DOI：
10.1159/000064713
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发表时间：
2002-01-01
期刊：
影响因子：
3.6
通讯作者：
Lowenfels, AB
中科院分区：
文献类型：
--
作者：
Lankisch, PG;Assmus, C;Lowenfels, AB
背景/目的：在世界范围内，胰腺癌的发病率是众所周知的，而急性胰腺炎和慢性胰腺炎的发病率则不为人所知。我们的研究旨在确定德国明确人群中所有三种胰腺疾病的发病率。研究方法：对1988年至1995年期间居住在吕讷堡县的所有急性（仅首次发作）和慢性胰腺炎以及胰腺癌患者的记录进行了评价。结果如下：急性胰腺炎、慢性胰腺炎和胰腺癌的粗发病率分别为19.7/100，000居民/年、6.4/100，000居民/年和7.8/100，000居民/年。在急性和慢性胰腺炎中，男性占主导地位，而在胰腺癌中，性别比例几乎相等。急性胰腺炎的发病率高峰在35-44岁年龄组，慢性胰腺炎为45-54岁，胰腺癌为65-75岁。急性胰腺炎的病因为胆源性（40%），酒精滥用（32%），未知（20%），其他（8%）。在慢性胰腺炎中，酒精滥用是72%的病因，28%的病因不明（特发性）。结论：这是第一次在定义明确的德国人群中获得的流行病学数据与所有三种胰腺疾病有关：急性胰腺炎（发病率、病因和严重程度）、慢性胰腺炎（发病率和病因）和胰腺癌（发病率）。在比急性胰腺炎高峰年龄组大10岁的年龄组中发生慢性胰腺炎的高峰发病率表明慢性胰腺炎在急性胰腺炎首次发作后的这段时间内发展。版权所有（C）2002 S. Karger AG、巴塞尔和IAP。
Background/Aims: Worldwide, the incidence of pancreatic cancer is very well known, that of acute pancreatitis and chronic pancreatitis not. Our study sought to determine the incidence of all three pancreatic diseases in a well-defined population in Germany. Methods: Records of all patients treated for acute (first attacks only) and chronic pancreatitis as well as pancreatic cancer from 1988 to 1995 and who resided in the county of Luneburg were evaluated. Results: The crude incidence rates for acute pancreatitis, chronic pancreatitis and pancreatic cancer per 100,000 inhabitants/year were 19.7, 6.4, and 7.8. In acute and chronic pancreatitis the male gender dominated, whereas in pancreatic carcinoma the gender ratio was almost even. Peak incidence for acute pancreatitis was in the age group of 35-44 years, for chronic pancreatitis 45-54, and for pancreatic cancer 65-75. Etiology of acute pancreatitis was biliary in 40%, alcohol abuse in 32%, unknown in 20%, and other in 8% of the patients. In chronic pancreatitis alcohol abuse was the etiology in 72% and unknown (idiopathic) in 28%. Conclusion: For the first time, epidemiological data obtained in a well-defined German population are being published relating to all three pancreatic diseases: acute pancreatitis (incidence rate, etiology and severity), chronic pancreatitis (incidence rate and etiology), and pancreatic carcinoma (incidence rate). A peak incidence of chronic pancreatitis occurring in an age group 10 years older than the peak age group for acute pancreatitis suggests that chronic pancreatitis develops during this time-frame following first attacks of acute pancreatitis. Copyright (C) 2002 S. Karger AG, Basel and IAP.