Estrogenic activity of alkylphenols, bisphenol S, and their chlorinated derivatives using a GFP expression system
Estrogenic activity of alkylphenols, bisphenol S, and their chlorinated derivatives using a GFP expression system
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DOI：
10.1016/j.etap.2004.05.009
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发表时间：
2005-01-01
影响因子：
4.3
通讯作者：
Terao, Y
中科院分区：
文献类型：
--
作者：
Kuruto-Niwa, R;Nozawa, R;Terao, Y
烷基酚乙氧基酸酯是一种应用广泛的非离子表面活性剂，可被生物降解为壬基酚（NP）和t-辛基酚（OP）等烷基酚类化合物，短链乙氧基酸酯(NP -单乙氧基酸酯（NP2EO）和NP-二氧基酸酯（NP2EO）等短链乙氧基酸酯，以及4-t-辛基苯氧基乙酸（OP1EC）等烷基苯氧基羧酸。双酚S （BPS）比双酚A （BRA）更耐热、更耐光，因此取代了BPA。这些化学物质可以在废水处理过程中进行氯化处理。我们合成了这些化合物及其氯化衍生物，并利用GFP表达系统估计它们的雌激素活性。nt相关化合物的EC50为NP b> CINP排名> diCINP > NP2EO > CINP1EO > NP2EO。OP1EC的雌激素活性比亲本op低10倍。BPS显示出与BPA相当的雌激素活性。BPS相关化合物的EC50排序为BPA > BPS > triCIBPS > diCIBPS > CIBPS。其他测试的BPS衍生物没有雌激素活性。受试化学品的氯化处理并没有增强它们的雌激素活性。与某些氯化双酚a形成对比因此，我们的研究结果表明，即使在废水处理过程中人工产生了NP， OP和BPS的氯化衍生物。与母体化学物质——内分泌干扰物相比，雌激素含量更低。(C) 2004 Elsevier B.V.版权所有
Alkylphenol ethoxylates, widely used non-ionic surfactants, are biodegraded into alkylphenols such as nonylphenol (NP) and t-octylphenol (OP), short-chain ethoxylates such as NP-monoethoxylate (NP2EO) and NP-diethoxylate (NP2EO), and alkylphenoxy carboxylic acids such as 4-t-octylphenoxyacetic acid (OP1EC). Bisphenol S (BPS) is more heat-stable and photo-resistant than bisphenol A (BRA), and therefore replaces BPA. These chemicals could be chlorinated during wastewater treatment. We synthesized these compounds and their chlorinated derivatives to estimate their estrogenic activities using a GFP expression system. The EC50 of NT-related compounds was NP > CINP ranking > diCINP > NP2EO > CINP1EO > NP2EO. The estrogenic activity of OP1EC was 10 times less potent than parent OP. Furthermore. BPS showed comparable estrogenic activity with BPA. The EC50 ranking of BPS-related compounds was BPA > BPS > triCIBPS > diCIBPS > CIBPS. Other tested BPS derivatives had no estrogenic activity. Chlorination of the tested chemicals did not enhance their estrogenic activity. in contrast to certain chlorinated BPAs. Thus, our results demonstrated that chlorinated derivatives of NP, OP, and BPS, even if artificially produced during wastewater processing. were less estrogenic than their parent chemicals, known as endocrine disruptors. (C) 2004 Elsevier B.V. All rights reserved.