Circulating monocytes in acute pancreatitis.
Circulating monocytes in acute pancreatitis.
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急性胰腺炎中循环单核细胞。
DOI：
10.3389/fimmu.2022.1062849
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发表时间：
2022
影响因子：
7.3
通讯作者：
中科院分区：
文献类型：
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作者：
急性胰腺炎是一种常见的胃肠道疾病，其特征是胰腺外分泌部的炎症，并通过急性发作的腹痛表现出来。它经常与器官衰竭、胰腺坏死和死亡有关。越来越多的证据表明单核细胞-吞噬细胞、抗原呈递细胞和先天免疫系统的调节细胞-是急性胰腺炎炎症反应和随后器官衰竭的关键贡献者和调节者。本文综述了近年来循环单核细胞数量、表型和功能的动态变化及其调控机制的研究进展，重点介绍了脂质调节在急性胰腺炎中的作用。
Acute pancreatitis is a common gastrointestinal disease characterized by inflammation of the exocrine pancreas and manifesting itself through acute onset of abdominal pain. It is frequently associated with organ failure, pancreatic necrosis, and death. Mounting evidence describes monocytes - phagocytic, antigen presenting, and regulatory cells of the innate immune system - as key contributors and regulators of the inflammatory response and subsequent organ failure in acute pancreatitis. This review highlights the recent advances of dynamic change of numbers, phenotypes, and functions of circulating monocytes as well as their underling regulatory mechanisms with a special focus on the role of lipid modulation during acute pancreatitis.
DOI：
10.7759/cureus.16752
发表时间：
2021-07
期刊：
Cureus
影响因子：
--
作者：
Khan NA;Haider Kazmi SJ;Asghar MS;Singh M;Iqbal S;Jawed R;Muhammad L;Kirmani TA;Ahmed Khan S;Rajput IA
通讯作者：
Rajput IA