Arginine metabolism in vascular biology and disease
Arginine metabolism in vascular biology and disease
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DOI：
10.1191/1358863x05vm601oa
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发表时间：
2005-01-01
影响因子：
3.5
通讯作者：
Morris, SM
中科院分区：
文献类型：
--
作者：
Morris, SM
精氨酸代谢在心血管生理学和病理生理学中起主要作用，主要通过一氧化氮（NO）依赖性过程。然而，越来越明显的是，精氨酸代谢酶以外的NO脱氢酶也可以通过NO依赖性和非依赖性过程发挥重要作用。精氨酸在体内有三种来源，至少有五种哺乳动物酶或酶家族利用精氨酸作为底物。精氨酸可用性或各种精氨酸代谢途径的不同终产物的产生的变化可具有独特且深刻的生理后果。然而，我们对这些途径在整个身体、特定组织甚至单个细胞水平上的复杂相互作用的了解是不完整的。这篇综述将强调这一领域的最新研究结果，这些研究结果可能会提出更多的研究途径，从而更全面地了解健康和疾病中的心血管生理学。
Arginine metabolism plays a major role in cardiovascular physiology and path ophysiology, largely via nitric oxide (NO)-dependent processes. It is becoming increasingly apparent, however, that arginine metabolic enzymes other than the NO synthases can also play important roles via both NO-dependent and -independent processes. There are three sources of arginine in vivo and at least five mammalian enzymes or enzyme families that utilize arginine as substrate. Changes in arginine availability or in production of the different end products of the various arginine metabolic pathways can have distinct and profound physiologic consequences. However, our knowledge regarding the complex interplay between these pathways at the level of the whole body, specific tissues, and even individual cells, is incomplete. This review will highlight recent findings in this area that may suggest additional avenues of investigation that will allow a fuller understanding of cardiovascular physiology in health and disease.