Hematopoietic cell regulation by Rac1 and Rac2 guanosine triphosphatases
Hematopoietic cell regulation by Rac1 and Rac2 guanosine triphosphatases
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DOI：
10.1126/science.1088485
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发表时间：
2003-10-17
期刊：
影响因子：
56.9
通讯作者：
Williams, DA
中科院分区：
文献类型：
--
作者：
Gu, Y;Filippi, MD;Williams, DA
Rho鸟苷三磷酸酶（GTP酶）Rac1和Rac2是哺乳动物细胞中关键的信号调节因子。Rac1和Rac2小鼠等位基因的缺失会导致造血干/祖细胞（HSC/Ps）从骨髓大量进入血液，然而Rac1（-/-）而非Rac2（-/-）的HSC/Ps无法在受辐照的受体小鼠的骨髓中植入。相比之下，Rac2而非Rac1调节中性粒细胞中超氧化物的产生和定向迁移，并且在每种细胞类型中，这两种GTP酶在肌动蛋白组织、细胞存活和增殖中发挥不同的作用。因此，Rac1和Rac2调节造血发育和功能的独特方面。
The Rho guanosine triphosphatases (GTPases) Rac1 and Rac2 are critical signaling regulators in mammalian cells. The deletion of both Rac1 and Rac2 murine alleles leads to a massive egress of hematopoietic stem/progenitor cells (HSC/Ps) into the blood from the marrow, whereas Rac1(-/-) but not Rac2(-/-) HSC/Ps fail to engraft in the bone marrow of irradiated recipient mice. In contrast, Rac2, but not Rac1, regulates superoxide production and directed migration in neutrophils, and in each cell type, the two GTPases play distinct roles in actin organization, cell survival, and proliferation. Thus, Rac1 and Rac2 regulate unique aspects of hematopoietic development and function.