Criteria for the diagnosis of familial Mediterranean fever
Criteria for the diagnosis of familial Mediterranean fever
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DOI：
10.1002/art.1780401023
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发表时间：
1997-10-01
影响因子：
--
通讯作者：
Pras, M
中科院分区：
文献类型：
--
作者：
Livneh, A;Langevitz, P;Pras, M
客观的。建立一套新的家族性 MeMethods 诊断标准。研究人员对 27 种 FMF 的典型特征和表现进行了研究，以确定其在 105 名 FMF 患者和 106 名对照者中的患病率。研究组中FMF的诊断基于临床判断。对照组是患有各种其他疾病的患者，他们因经常与 FMF 发作有关的身体部位反复发作疼痛而到急诊室或门诊就诊。根据主要、次要和支持标准模型，观察到 FMF 患者中明显比对照组更常见的表现被纳入为 FMF 诊断提出的规则中。结果。建立了两套诊断标准。诊断FMF的保守标准是基于存在1个主要或2个次要标准，或1个次要加5个支持性标准，而诊断FMF的简单标准需要1个主要或2个次要标准，这2个标准集的敏感性和特异性分别> 95％和> 97％。结论。拟议的新标准具有高度敏感性和特异性，可用于轻松诊断 FMF 并将 FMF 与其他周期性发热性疾病区分开来。
Objective. To establish a new set of criteria for the diagnosis of familial MeMethods. Twenty-seven features and manifestations typical of FMF were studied to determine their prevalence in 105 patients with FMF and 106 controls. Diagnosis of FMF in the study group was based on clinical judgment. Controls were patients with a variety of other diseases who presented to the emergency room or outpatient clinics with recurrent episodes of pain in body sites usually involved in FMF attacks, Manifestations observed to be significantly more common in FMF patients than in controls were incorporated into the rule proposed for diagnosis of FMF, based on a model of major, minor, and supportive criteria,Results. Two sets of diagnostic criteria were established. A conservative criteria set for diagnosis of FMF was based on the presence of 1 major or 2 minor criteria, or 1 minor plus 5 supportive criteria, and a simple criteria set for diagnosis of FMF required 1 major or 2 minor criteria, The sensitivity and specificity of these 2 criteria sets were >95% and >97%, respectively.Conclusion. The proposed new sets of criteria were highly sensitive and specific, and could be used to readily diagnose FMF and to distinguish FMF from other periodic febrile diseases.