Terminal loop-mediated control of microRNA biogenesis
Terminal loop-mediated control of microRNA biogenesis
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DOI：
10.1042/bst20120053
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发表时间：
2012-08-01
影响因子：
3.9
通讯作者：
Michlewski, Gracjan
中科院分区：
文献类型：
--
作者：
Choudhury, Nila Roy;Michlewski, Gracjan
miRNA (microRNA) 生物发生的调节塑造了活细胞中 miRNA 的特征，有助于细胞的身份和功能。重要的是，异常的 miRNA 水平与多种人类病理状态有关。近年来，许多蛋白质已被证明可以在 Drosha 和 Dicer 切割水平上调节 miRNA 的生物发生。这些因子中很大一部分通过与 miRNA 祖细胞的 TL（末端环）区域结合来调节 miRNA 的产生。在本文中，我们回顾了目前关于 pri-miRNA（初级 miRNA）和 pre-miRNA（前体 miRNA）TL 参与 miRNA 生物发生调控的知识。
Regulation of miRNA (microRNA) biogenesis shapes the profiles of miRNAs in the living cell, contributing to cell identity and function. Importantly, aberrant miRNA levels have been linked to a variety of human pathological states. In recent years, a number of proteins have been shown to regulate the miRNA biogenesis at the level of Drosha and Dicer cleavage. A large proportion of these factors regulate miRNA production through binding to the TL (terminal loop) regions of miRNA progenitors. In the present paper, we review the current knowledge about pri-miRNA (primary miRNA) and pre-miRNA (precursor miRNA) TL involvement in the regulation of miRNA biogenesis.