Racial differences in weathering and its associations with psychosocial stress: The CARDIA study
Racial differences in weathering and its associations with psychosocial stress: The CARDIA study
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DOI：
10.1016/j.ssmph.2018.11.003
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发表时间：
2019-04-01
影响因子：
4.7
通讯作者：
Kiefe, Catarina, I
中科院分区：
文献类型：
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作者：
Forrester, Sarah;Jacobs, David;Kiefe, Catarina, I
生物学年龄（BA）是一个结构，捕获加速生物老化归因于“磨损”从各种曝光;我们测量BA和风化，定义为BA和实足年龄之间的差异，以及它们与种族和心理社会因素的关联在中年双种族队列。我们使用了1985-2016年在美国4个城市进行的年轻人冠状动脉风险研究（CARDIA）的数据，以检查48-60岁成年人的风化情况。我们使用选定的生物标志物通过Klemera和Doubal方法估计BA。我们评估了风化和心理社会措施之间的整体和种族特定的关联。对于纳入的2694名参与者，黑人的BA（SD）比他们的实际年龄大2.6（11.8）岁，而白人的平均BA比他们的实际年龄小3.5（10.0）岁（黑人比白人快6.1年）。属于更多的社会群体与较少的风化在黑人，但不是白人，多变量调整后，较低的SES和更多的抑郁症状与更多的风化在黑人之间比白人。我们证实了风化的种族差异，并新记录了类似的心理社会因素可能比白人对黑人的生物健康造成更大的损失。
Biological age (BA) is a construct that captures accelerated biological aging attributable to "wear and tear" from various exposures; we measured BA and weathering, defined as the difference between BA and chronological age, and their associations with race and psychosocial factors in a middle-aged bi-racial cohort. We used data from the Coronary Artery Risk in Young Adults study (CARDIA), conducted in 4 U.S. cities from 1985-2016 to examine weathering for adults aged 48-60 years. We estimated BA via the Klemera and Doubal method using selected biomarkers. We assessed overall and race-specific associations between weathering and psychosocial measures. For the 2694 participants included, Blacks had a BA (SD) that was 2.6 (11.8) years older than their chronological age while the average BA among Whites was 3.5 (10.0) years younger than their chronological age (Blacks weathered 6.1 years faster than Whites). Belonging to more social groups was associated with less weathering in Blacks but not Whites, and after multivariable adjustment, lower SES and more depressive symptoms were associated with more weathering among Blacks than among Whites. We confirmed racial differences in weathering, and newly documented that similar psychosocial factors may take a greater toll on the biological health of Blacks than Whites.