Response of Toll-like receptors in experimental Guillain-Barre syndrome: A kinetic analysis
Response of Toll-like receptors in experimental Guillain-Barre syndrome: A kinetic analysis
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DOI：
10.1016/j.neulet.2012.04.077
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发表时间：
2012-06-19
影响因子：
2.5
通讯作者：
Walter, Silke
中科院分区：
文献类型：
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作者：
Gries, Manuela;Davies, Laura;Walter, Silke
格林-巴利综合征（Guillain-Barre syndrome，GBS）是一种由外周神经系统细胞免疫和体液免疫相互作用引起的自身免疫性疾病。Toll样受体（TLR）是先天免疫的关键参与者，在适应性免疫中具有调节功能。在这项研究中，我们系统地研究了TLRs在坐骨神经和淋巴器官的小鼠实验性自身免疫性神经炎的疾病过程中，并从格林-巴利患者的血液中的表达模式。确定了动力学响应模式，其特征在于T细胞上的TLR 2、6和11以及APC上的TLR 4和6的显著上调，而TLR 1表达降低。此外，检测到促进疾病的细胞因子白细胞介素-（IL）17 A的表达增强。对GBS患者的进一步分析显示，TLR 2、TLR 4和TLR 6 mRNA的上调与疾病严重程度呈负相关。TLR表达模式的首次系统分析可能有助于阐明TLR在GBS病理生理学中的作用。(C)2012爱思唯尔爱尔兰有限公司保留所有权利。
Guillain-Barre syndrome (GBS) is an autoimmune disorder caused by the interaction between cellular and humoral immune responses in the peripheral nervous system. Toll-like receptors (TLRs) are key players in innate and have regulatory functions in adaptive immunity. In this study, we systematically examined expression patterns of TLRs in sciatic nerve and lymphoid organs during the disease course of murine experimental autoimmune neuritis and in blood from Guillain-Barre patients. A kinetic response pattern was identified, characterized by a pronounced up-regulation of TLR2, 6 and 11 on T cells and TLR4 and 6 on APCs, while TLR1 expression was decreased. Moreover, an enhanced expression of the disease promoting cytokine Interleukin-(IL)17A was detected. Additional analysis of GBS patients revealed an up-regulation of TLR2, TLR4 and TLR6 mRNA, negatively correlated with disease severity. This first systematic analysis of TLR expression pattern may contribute to elucidating the role of TLRs in GBS pathophysiology. (C) 2012 Elsevier Ireland Ltd. All rights reserved.