Role of Ferroptosis in Lung Diseases.
Role of Ferroptosis in Lung Diseases.
复制标题
铁死亡在肺部疾病中的作用
DOI：
10.2147/jir.s307081
复制
发表时间：
2021
影响因子：
4.5
通讯作者：
Lv X
中科院分区：
文献类型：
--
作者：
Xu W;Deng H;Hu S;Zhang Y;Zheng L;Liu M;Chen Y;Wei J;Yang H;Lv X
铁下垂是一种新型的程序性细胞死亡，其特征是细胞内铁积聚和脂质过氧化，导致氧化应激和细胞死亡。铁、脂和氨基酸的代谢以及多条信号通路精确地调节着下垂的过程。新的证据表明，铁下垂参与了多种病理状态和疾病的发生和发展，如感染、神经变性、组织缺血再灌注损伤和免疫性疾病。最近的研究也表明，铁性下垂在急性肺损伤、慢性阻塞性肺疾病、肺纤维化、肺部感染和哮喘的发病机制中起着关键作用。本文就铁下垂的调控机制及其与铁、脂、氨基酸代谢的关系以及几种信号转导途径的最新研究进展作一综述。此外，我们回顾了铁性下垂在肺部疾病发病机制中的作用，并讨论了铁性下垂作为各种肺部疾病的新的治疗靶点。
Ferroptosis is a new type of programmed cell death characterized by intracellular iron accumulation and lipid peroxidation that leads to oxidative stress and cell death. The metabolism of iron, lipids, and amino acids and multiple signalling pathways precisely regulate the process of ferroptosis. Emerging evidence has demonstrated that ferroptosis participates in the occurrence and progression of various pathological conditions and diseases, such as infections, neurodegeneration, tissue ischaemia-reperfusion injury and immune diseases. Recent studies have also indicated that ferroptosis plays a critical role in the pathogenesis of acute lung injury, chronic obstructive pulmonary disease, pulmonary fibrosis, pulmonary infection and asthma. Herein, we summarize the latest knowledge on the regulatory mechanism of ferroptosis and its association with iron, lipid and amino acid metabolism as well as several signalling pathways. Furthermore, we review the contribution of ferroptosis to the pathogenesis of lung diseases and discuss ferroptosis as a novel therapeutic target for various lung diseases.