MODULATION OF OSTEOGENESIS IN FETAL BONE RUDIMENTS BY MECHANICAL-STRESS INVITRO
MODULATION OF OSTEOGENESIS IN FETAL BONE RUDIMENTS BY MECHANICAL-STRESS INVITRO
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DOI：
10.1016/0021-9290(91)90381-v
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发表时间：
1991-01-01
影响因子：
2.4
通讯作者：
VELDHUIJZEN, JP
中科院分区：
文献类型：
--
作者：
BURGER, EH;KLEINNULEND, J;VELDHUIJZEN, JP
综述了在间歇性机械应力作用下发育中的骨器官培养的研究进展。这些骨骼中的矿物质代谢是通过暴露于生理强度的动态应力来调节的。对长骨的有限元应力分析表明，在器官培养过程中，静水压力会在矿化/非矿化组织界面产生显著的剪切应力和膨胀应力。体外机械应力对基质生成细胞（软骨细胞、成骨细胞）和基质再吸收细胞（破骨细胞）均有影响。器官培养模型为在细胞和组织水平上研究机械应力对骨组织的影响提供了一定的机会。
Studies of organ cultures of developing bone subjected to intermittent mechanical stress are reviewed. Mineral metabolism in these bones is modulated by exposure to dynamic stress of physiological magnitude. Finite element stress analysis of long bone rudiments shows that hydrostatic pressure during organ culture produces significant shear stresses at mineralized/non-mineralized tissue interfaces, in addition to dilatational stress. Both matrix producing cells (chondrocytes, osteoblasts) and matrix resorbing cells (osteoclasts) are affected by mechanical stress in vitro. The organ culture model offers certain opportunities for studying effects of mechanical stress on skeletal tissue at the cell and tissue level.