Depression and immunity: Inflammation and depressive symptoms in multiple sclerosis
Depression and immunity: Inflammation and depressive symptoms in multiple sclerosis
复制标题
DOI：
10.1016/j.ncl.2006.03.007
复制
发表时间：
2006-08-01
影响因子：
2.4
通讯作者：
Irwin, Michael R.
中科院分区：
文献类型：
--
作者：
Gold, Stefan M.;Irwin, Michael R.
越来越多的证据表明，患有重度抑郁症的患者显示免疫标志物的改变，包括促炎细胞因子活性和炎症的增加。中枢神经系统炎症是多发性硬化症（MS）的病理标志。受这种疾病影响的患者也表现出抑郁症的高发病率。从动物研究中积累的证据表明，MS中抑郁和疲劳的某些方面可能与炎症标志物有关。本文回顾了该领域的现有知识，并说明了疾病行为模型如何应用于研究炎症性神经系统疾病中的抑郁症状。
An increasing body of evidence suggests that patients who have major depressive disorder show alterations in immunologic markers including increases in proinflammatory cytokine activity and inflammation. Inflammation of the central nervous system is a pathologic hallmark of multiple sclerosis (MS). Patients affected by this disease also show a high incidence of depression. Accumulating evidence from animal studies suggests that some aspects of depression and fatigue in MS may be linked to inflammatory markers. This article reviews the current knowledge in the field and illustrates how the sickness behavior model may be applied to investigate depressive symptoms in inflammatory neurologic diseases.