Non-Hodgkin lymphoma in Jordan. Types and patterns of 111 cases classified according to the WHO classification of hematological malignancies.
Non-Hodgkin lymphoma in Jordan. Types and patterns of 111 cases classified according to the WHO classification of hematological malignancies.
复制标题
约旦的非霍奇金淋巴瘤。
DOI：
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发表时间：
2004
影响因子：
1.6
通讯作者：
Hasan S. Khalidi
中科院分区：
文献类型：
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作者：
N. Almasri;Mahmud A Habashneh;Hasan S. Khalidi
目的
非霍奇金淋巴瘤（NHL）是约旦最常见的恶性肿瘤之一。本研究的主要目的是：1.分类NHL病例在约旦，使用新的世界卫生组织（WHO）分类系统，2。确定约旦最常见的NHL类型，以及3.比较淋巴瘤类型和模式在约旦与周边国家和西方。
方法
我们研究了1996年至1999年诊断的所有NHL病例，在约旦的2个主要医疗中心，以确定其主要类型和模式。2000年，在约旦伊尔比德的约旦科技大学病理学系，使用免疫组化抗体组（包括CD 3、CD 15、CD 20、CD 30、CD 43、CD 45和CD 45 RO）对111例确诊的NHL病例进行了重新检查和免疫表型分析。根据最近提出的WHO血液系统恶性肿瘤系统对确诊的NHL病例进行重新分类。
结果
NHL病例的中位年龄为44岁（范围2-85岁）。绝大多数病例为B细胞表型;只有14%的病例为T细胞淋巴瘤。大多数病例为侵袭性中等至高级大细胞类型。弥漫性大B细胞淋巴瘤（DLBCL）包括53%的NHL和62%的B细胞NHL。惰性淋巴瘤是罕见的，占所有NHL病例的14%。29例病例见于小于20岁的患者。伯基特淋巴瘤是儿童NHL的最大类型（55%），其次是弥漫性大细胞型和淋巴母细胞型。
结论
惰性淋巴瘤在约旦很少见，占所有NHL的不到15%。另一方面，侵袭性淋巴瘤占约旦NHL的大多数。伯基特淋巴瘤影响不到10岁的儿童，中位数为4.5岁。这些观察结果表明，约旦的NHLs与西方国家的NHLs有不同的类型分布和模式。
OBJECTIVE
Non-Hodgkin lymphoma (NHL) is one of the most frequent malignancies in Jordan. The aims of this study are: 1. To classify NHL cases in Jordan, using the new World Health Organization (WHO) classification system, 2. To identify the most common types of NHL in Jordan, and 3. To compare lymphoma types and patterns in Jordan with those in surrounding countries and the West.
METHODS
We studied all NHL cases, diagnosed during 1996 through to 1999 inclusive, at 2 major medical centers in Jordan, in order to identify their main types and patterns. One hundred and eleven cases of confirmed NHLs were reexamined and immunophenotyped in the year 2000, at the Department of Pathology, Jordan University of Science and Technology, Irbid, Jordan, using an immunohistochemical panel of antibodies, including CD3, CD15, CD20, CD30, CD43, CD45 and CD45RO. Confirmed NHL cases were reclassified according to the recently proposed WHO system of Hematological Malignancies.
RESULTS
The median age of NHL cases was 44-years (range 2-85). The vast majority of cases were of B-cell phenotype; only 14% of the cases were T-cell lymphomas. Most of the cases were of the aggressive intermediate to high-grade large cell type. Diffuse large B-cell lymphoma (DLBCL) comprised 53% of NHLs and 62% of B-cell NHLs. Indolent lymphomas were uncommon, comprising 14% of all NHL cases. Twenty-nine cases were seen among patients less than 20-years. Burkitt lymphoma represented the largest group (55%) of the childhood NHLs followed by diffuse large cell and lymphoblastic types.
CONCLUSION
Indolent lymphomas are rare in Jordan and account for less than 15% of all NHLs. Aggressive lymphomas; on the other hand, account for the majority of NHLs in Jordan. Burkitt lymphoma affected children less than 10-years of age with a median of 4.5-years. These observations indicate that NHLs in Jordan have different type distribution and patterns from those seen in the West.
非霍奇金淋巴瘤：病理学、分期、治疗。
影响因子：
2.6
作者：
Hoppe,RT
通讯作者：
Hoppe,RT