Plasma membrane Ca2+ ATPase 2 contributes to short-term synapse plasticity at the parallel fiber to Purkinje neuron synapse
Plasma membrane Ca2+ ATPase 2 contributes to short-term synapse plasticity at the parallel fiber to Purkinje neuron synapse
复制标题
DOI：
10.1523/jneurosci.0069-07.2007
复制
发表时间：
2007-04-04
影响因子：
5.3
通讯作者：
Knopfel, Thomas
中科院分区：
文献类型：
--
作者：
Empson, Ruth M.;Garside, Molly L.;Knopfel, Thomas
质膜Ca2+ atp酶2 （PMCA2）是一种快速、高效的机制来控制神经元和其他可兴奋细胞的静息胞浆Ca2+和Ca2+漂移。PMCA2在小脑中的强表达和PMCA β(-/-)敲除小鼠表现出的小脑行为缺陷都表明它对小脑回路动力学的重要性。在这里，我们为突触前pmca2介导的Ca2+挤出对小脑浦肯野神经元突触平行纤维短期可塑性的影响提供了直接的功能证据。在缺乏PMCA2的情况下，浦肯野神经元的剧烈结构改变也表明，这种快速PMCA2亚型对小脑功能的发育和维持有强烈的影响。
Plasma membrane Ca2+ ATPase 2 (PMCA2) is a fast, highly effective mechanism to control resting cytosolic Ca2+ and Ca2+ excursions in neurons and other excitable cells. The strong expression of PMCA2 in the cerebellum and the cerebellar behavioral deficits presented by PMCA beta(-/-) knock-out mice all point to its importance for cerebellar circuit dynamics. Here, we provide direct functional evidence for the influence of presynaptic PMCA2-mediated Ca2+ extrusion for short-term plasticity at cerebellar parallel fiber to Purkinje neuron synapses. Dramatic structural alterations to the Purkinje neurons in the absence of PMCA2 also suggest a strong influence of this fast PMCA2 isoform for development and maintenance of cerebellar function.