Meta-Analysis of the Brain-Derived Neurotrophic Factor Gene (BDNF) Val66Met Polymorphism in Anxiety Disorders and Anxiety-Related Personality Traits
Meta-Analysis of the Brain-Derived Neurotrophic Factor Gene (BDNF) Val66Met Polymorphism in Anxiety Disorders and Anxiety-Related Personality Traits
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DOI：
10.1159/000182892
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发表时间：
2008-01-01
影响因子：
3.2
通讯作者：
Boccia, Stefania
中科院分区：
文献类型：
--
作者：
Frustaci, Alessandra;Pozzi, Gino;Boccia, Stefania
目的：脑源性神经营养因子（BDNF）可能参与焦虑的发病机制。我们进行了meta分析来评估BDNF Val66Met（缬氨酸、蛋氨酸）多态性与焦虑障碍（AD）或焦虑相关人格特质（ARPT）之间的关系。方法：检索至2007年12月的Medline、Embase和PsycINFO数据库。我们研究了与BDNF Val66Met多态性相关的3个结局：(1)临床诊断为AD的病例；(2)未诊断为精神病的被试的ARPT，采用NEO-PI、NEO-PI- r、NEO-FFI中的神经质量表，或采用(3)三维人格问卷（TPQ）中的伤害避免（HA）量表或其扩展版气质与性格量表（TCI）进行评估。结果：AD共7项病例对照研究，包括1092例病例和8394例对照，神经质5项横断面研究（n = 1633）， HA 4项横断面研究（n = 607）。与Val/Val组相比，Met/Met组和Val/Met组的神经质评分均有统计学意义的降低[SMD分别为-0.24 （95% Cl: -0.44, -0.04）和-0.11 (95% Cl: -0.22, -0.01)]。BDNF Val66Met多态性与AD [Met/Met vs. Val/Val OR = 1.13 (95% Cl: 0.85-1.52)]或HA [Met/Met vs. Val/Val SMD = 0.11 (95% Cl: -0.19, 0.42)]之间无显著关联。结论：关于该主题的研究数量少，样本量有限，以及焦虑表型定义的内部限制，建议在解释这些结果时谨慎。需要更多的研究来证实这些结果，这些研究可能会调查与其他基因和环境暴露的相互作用。版权所有(c) 2008 S. Karger AG，巴塞尔
Objective: Brain-derived neurotrophic factor (BDNF) is potentially involved in the pathogenesis of anxiety. We carried out meta-analyses to evaluate the relationship between the BDNF Val66Met (valine, methionine) polymorphism and anxiety disorders (AD) or anxiety-related personality traits (ARPT). Methods: Medline, Embase and PsycINFO were searched up to December 2007. We investigated 3 outcomes related to BDNF Val66Met polymorphisms: (1) clinically diagnosed cases of AD; (2) ARPT in subjects without psychiatric diagnoses, assessed either by the Neuroticism scale of NEO-Personality Inventory forms (NEO-PI, NEO-PI-R, NEO-FFI), or by (3) the Harm Avoidance (HA) scale of Tridimensional Personality Questionnaire (TPQ) or its extended version Temperament and Character Inventory (TCI). Results: Seven case-control studies were selected for AD, including 1,092 cases and 8,394 controls, while 5 cross-sectional studies for Neuroticism (n = 1,633) and 4 for HA (n = 607). Both Met/Met and Val/Met individuals, as compared to Val/Val, showed a statistically significant lower Neuroticism score [SMD = -0.24 (95% Cl: -0.44, -0.04), and -0.11 (95% Cl: -0.22, -0.01), respectively]. No significant association was found between BDNF Val66Met polymorphism and AD [OR = 1.13 (95% Cl: 0.85-1.52) for Met/Met versus Val/Val] or HA [SMD = 0.11 (95% Cl: -0.19, 0.42) for Met/Met vs. Val/Val]. Conclusions: The low number of studies on this topic and their limited sample size, along with the inner limits in the definition of anxiety phenotypes, suggest caution in the interpretation of these results. Larger additional studies possibly investigating the interaction with other genes and environmental exposures are required to confirm these results. Copyright (c) 2008 S. Karger AG, Basel