Cellular transport and homeostasis of essential and nonessential metals.
Cellular transport and homeostasis of essential and nonessential metals.
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DOI：
10.1039/c2mt00185c
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发表时间：
2012-07
期刊：
影响因子：
--
通讯作者：
Aschner M
中科院分区：
文献类型：
--
作者：
Martinez-Finley EJ;Chakraborty S;Fretham SJ;Aschner M
金属对细胞有许多有害或有益的影响，但首先它们必须进入细胞。生物体已经进化出运输机制，将所需或必需的金属运送到细胞中。非必需金属通常通过为必需金属提供的机制进入细胞。许多工作已经完成，以提高我们对这些金属如何在等离子体和细胞器膜上运输的理解。本文综述了这些金属运输过程。
Metals can have a number of detrimental or beneficial effects in the cell, but first they must get in. Organisms have evolved transport mechanisms to get metals that are required, or essential into the cell. Nonessential metals often enter the cell through use of the machinery provided for essential metals. Much work has been done to advance our understanding of how these metals are transported across the plasma and organelle membranes. This review provides an overview of these metal transport processes.