Analysis of behavioral constraints and the neuroanatomy of fear to the predator odor trimethylthiazoline: A model for animal phobias
Analysis of behavioral constraints and the neuroanatomy of fear to the predator odor trimethylthiazoline: A model for animal phobias
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DOI：
10.1016/j.neubiorev.2008.05.006
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发表时间：
2008-09-01
影响因子：
8.2
通讯作者：
Davis, Cameron
中科院分区：
文献类型：
--
作者：
Rosen, Jeffrey B.;Pagani, Jerome H.;Davis, Cameron
特定恐惧症，包括动物恐惧症，是最常见的焦虑症，具有很强的先天和遗传成分。研究啮齿类动物对捕食者的先天恐惧的神经生物学和环境限制可能有助于阐明人类动物恐惧症的机制。本文综述了从狐狸粪便中分离出的三甲基噻唑啉（TMT）引起大鼠先天性恐惧的研究。TMT诱导无条件冻结和其他防御反应，这些反应受TMT剂量和测试环境的形状调节。高层管理团队诱发的情境条件作用会发生，但会受到环境的制约。损害研究表明，杏仁核回路subserving恐惧条件是不必要的无条件恐惧TMT。此外，内侧下丘脑防御回路也似乎没有必要的无条件冻结TMT，而电路，包括杏仁核内侧核和终纹床核是必不可少的。这些研究结果的重要性，先天捕食者的气味恐惧啮齿动物在人类的动物恐惧症进行了讨论。(C)2008爱思唯尔有限公司保留所有权利。
Specific phobias, including animal phobias, are the most common anxiety disorders, and have a strong innate and genetic component. Research on the neurobiology and environmental constraints of innate fear of predators in rodents may be useful in elucidating mechanisms of animal phobias in humans. The present article reviews research on innate fear in rats to trimethylthiazoline (TMT), an odor originally isolated from fox feces. TMT induces unconditioned freezing and other defensive responses that are regulated by the dose of TMT and the shape of the testing environment. Contextual conditioning induced by TMT occurs, but is constrained by the environment. Lesion studies indicate the amygdala circuitry subserving fear conditioning is not necessary for unconditioned fear to TMT. Additionally, a medial hypothalamic defensive circuit also appears not necessary for unconditioned freezing to TMT, whereas circuits that include the medial nucleus of the amygdala and the bed nucleus of the stria terminalis are essential. The importance of these findings of innate predator odor fear in rodents to animal phobias in humans is discussed. (C) 2008 Elsevier Ltd. All rights reserved.