Two new lankacidin-related metabolites from Streptomyces sp HS-NF-1178
Two new lankacidin-related metabolites from Streptomyces sp HS-NF-1178
复制标题
DOI：
10.1038/s41429-017-0004-0
复制
发表时间：
2018-03-01
影响因子：
3.3
通讯作者：
Wang, Xiang-Jing
中科院分区：
文献类型：
--
作者：
Lu, Chang;Li, Jin-Meng;Wang, Xiang-Jing
从链霉菌HS-NF-1178的发酵液中分离得到两个新的兰卡酸酯代谢产物2，18-断链兰卡酸酯醇A（1）、2，18-断链兰卡酸酯醇B（2）和一个已知化合物兰卡酸酯醇（3）。它们的结构确定的基础上，光谱分析，包括1D和2D NMR技术以及ESI-MS和与文献中的数据比较。这两个新化合物，特别是化合物1，显示出较强的抗肿瘤活性。
Two new lankacidin-related metabolites, 2,18-seco-lankacidinol A (1), 2,18-seco-lankacidinol B (2) and a known compound, lankacidinol (3), were isolated from the fermentation broth of Streptomyces sp. HS-NF-1178. Their structures were determined on the basis of spectroscopic analysis, including 1D and 2D NMR techniques as well as ESI-MS and comparison with data from the literature. These two new compounds, especially compound 1, exhibited potent antitumor activity.