Sex and performance level effects on brain activation during a verbal fluency task: A functional magnetic resonance imaging study
Sex and performance level effects on brain activation during a verbal fluency task: A functional magnetic resonance imaging study
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DOI：
10.1016/j.cortex.2007.09.006
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发表时间：
2009-02-01
期刊：
影响因子：
3.6
通讯作者：
Capron, Christiane
中科院分区：
文献类型：
--
作者：
Gauthier, Christophe T.;Duyme, Michel;Capron, Christiane
神经影像学研究语言流畅性（VF）的神经相关性集中在性别差异，而不考虑行为的变化。然而，这种语言能力的群体差异可能解释了男性和女性之间引起的神经认知差异。本研究的目的是测试性别和性能水平的影响，以及这些对大脑激活的组合。四个样本的11名健康的学生（N = 44）的基础上选择的性别和对比VF分数，高流畅性（HF）与低流畅性（LF），在扫描过程中进行了隐蔽的语音VF任务。进行组内和组间分析。与之前的研究一致，对于每个样本，全组分析报告了额下回（IFG）、小脑、前扣带皮层（ACC）、内侧额回（mFG）、上级（SPL）和顶下小叶（IPL）、下视觉区、小脑、丘脑和基底神经节的激活。组间分析表明，性别和性能之间的相互作用，在右楔前叶，左ACC，右IFG和左背外侧前额叶皮层（dlPFC）。HF组右侧楔前叶和左侧dlPFC的激活程度高于LF组。LF男性表现出更多的激活在右侧IFG比HF的和LF女性引起更多的激活在左侧ACC比HF的。无论左侧颞下回（ITG）、小脑、前扣带皮层和后扣带皮层以及右侧上级额回（SFG）和dlPFC、舌回和ACC的表现如何，都发现了性别主效应，男性比女性引起更大的激活。无论性别如何，左侧ACC和左侧小脑均存在性能主效应。低频受试者有更强的激活比HF的ACC，而HF的受试者表现出更强的激活在小脑。ACC三个独立次区域的活动分别与性别、成绩及其相互作用有关。我们的研究结果强调，需要考虑性别和性能水平的功能成像研究室颤。(c)2007 Elsevier Srl. All rights reserved.
Neuroimaging studies investigating the neural correlates of verbal fluency (VF) focused on sex differences without taking into account behavioural variation. Nevertheless, group differences in this verbal ability might account for neurocognitive differences elicited between men and women. The aim of this study was to test sex and performance level effects and the combination of these on cerebral activation. Four samples of 11 healthy Students (N = 44) selected on the basis of sex and contrasted VF scores, high fluency (HF) versus low fluency (LF), performed a covert phonological VF task during scans. Within-nd between-group analyses were conducted. Consistent with previous studies, for each sample, the whole-group analysis reported activation in the inferior frontal gyrus (IFG), insula, anterior cingulate cortex (ACC), medial frontal gyrus (mFG), superior (SPL) and inferior parietal lobules (IPL), inferior visual areas, cerebellum, thalamus and basal ganglia. Between-group analyses showed an interaction between sexes and performances in the right precuneus, left ACC, right IFG and left dorsolateral prefrontal cortex (dlPFC). HF men showed more activation than LF ones in the right precuneus and left dlPFC. LF men showed more activation in the right IFG than HF ones and LF women elicited more activation in the left ACC than HF ones. A sex main effect was found regardless of performance in the left inferior temporal gyrus (ITG), cerebellum, anterior and posterior cingulate cortexes and in the right superior frontal gyrus (SFG) and dlPFC, lingual gyrus and ACC, with men eliciting significantly greater activations than women. A performance main effect was found for the left ACC and the left cerebellum regardless of sex. LF subjects had stronger activations than HF ones in the ACC whereas HF subjects showed stronger activations in the cerebellum. Activity in three discrete subregions of the ACC is related to sex, performance and their interaction, respectively. Our findings emphasize the need to consider sex and performance level in functional imaging studies of VF. (c) 2007 Elsevier Srl. All rights reserved.